ID   INO1_MYCTO              Reviewed;         367 AA.
AC   P9WKI0; L0T457; P71703;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=IPS;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=MI-1-P synthase;
DE            Short=MIP synthase;
GN   Name=ino1; OrderedLocusNames=MT0052;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Catalyzes the conversion of glucose 6-phosphate to 1D-myo-
CC       inositol 3-phosphate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK44274.1; -; Genomic_DNA.
DR   PIR; F70912; F70912.
DR   RefSeq; WP_003400492.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WKI0; -.
DR   SMR; P9WKI0; -.
DR   EnsemblBacteria; AAK44274; AAK44274; MT0052.
DR   GeneID; 45424005; -.
DR   KEGG; mtc:MT0052; -.
DR   PATRIC; fig|83331.31.peg.52; -.
DR   HOGENOM; CLU_050011_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR017815; Myo-inos-1-P_Synthase_actino.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR03450; mycothiol_INO1; 1.
PE   3: Inferred from homology;
KW   Inositol biosynthesis; Isomerase.
FT   CHAIN           1..367
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000427650"
SQ   SEQUENCE   367 AA;  39994 MW;  CC791A07FA849953 CRC64;
     MSEHQSLPAP EASTEVRVAI VGVGNCASSL VQGVEYYYNA DDTSTVPGLM HVRFGPYHVR
     DVKFVAAFDV DAKKVGFDLS DAIFASENNT IKIADVAPTN VIVQRGPTLD GIGKYYADTI
     ELSDAEPVDV VQALKEAKVD VLVSYLPVGS EEADKFYAQC AIDAGVAFVN ALPVFIASDP
     VWAKKFTDAG VPIVGDDIKS QVGATITHRV LAKLFEDRGV QLDRTMQLNV GGNMDFLNML
     ERERLESKKI SKTQAVTSNL KREFKTKDVH IGPSDHVGWL DDRKWAYVRL EGRAFGDVPL
     NLEYKLEVWD SPNSAGVIID AVRAAKIAKD RGIGGPVIPA SAYLMKSPPE QLPDDIARAQ
     LEEFIIG