ID   INO1_NICPA              Reviewed;         510 AA.
AC   Q9SSV4;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
GN   Name=INPS1;
OS   Nicotiana paniculata.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=62141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hashimoto A., Yamada S., Komori T.;
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AB032073; BAA84084.1; -; mRNA.
DR   AlphaFoldDB; Q9SSV4; -.
DR   SMR; Q9SSV4; -.
DR   UniPathway; UPA00823; UER00787.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism.
FT   CHAIN           1..510
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195194"
SQ   SEQUENCE   510 AA;  56385 MW;  415B81C27A267666 CRC64;
     MFIENFKVES PNVKYTESEI HSVYDYQTTE LVHDEKNGTY QWTVKPKTVK YEFKTDVHVP
     KLGVMLVGWG GNNGSTLTGG VIANREGISW ATKDKVQQAN YFGSLTQAST IRVGSFNGEE
     IYAPFKSLLP MVNPDDVVFG GWDISDMNLA DAMARAKVFD IDLQKQLRPY MESMVPLPGI
     YDPDFIAANQ GSRANNVIKG TKKEQIDQII KDIREFKEKN KVDKVVVLWT ANTERYSNVV
     VGLNDTMENL FASVDRNEAE ISPSTLYAIA CILENVPFIN GSPQNTFVPG LIDLAIKKNT
     LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
     NVVDDMVSSN AILYEPGEHP DHVVVIKYVP YVGDSKRAMD EYTSEIFMGG KNTIVLHNTC
     EDSLLAAPII LDLVLLAELS TRIQLKAEGE GKFHSFHPVA TILSYLTKAP LVPPGTPVVN
     ALSKQRAMLE NILRACVGLA PENNMILEYK