INO1_PHAVU
ID INO1_PHAVU Reviewed; 511 AA.
AC Q41107;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Inositol-3-phosphate synthase;
DE Short=MIP synthase;
DE EC=5.5.1.4;
DE AltName: Full=Myo-inositol 1-phosphate synthase;
DE Short=IPS;
DE Short=MI-1-P synthase;
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Taylor's horticultural; TISSUE=Root;
RA Wang X., Johnson M.D.;
RT "An isoform of 1L-myo-Inositol 1-phosphate synthase (EC 5.5.1.4) from
RT Phaseolus vulgaris.";
RL (er) Plant Gene Register PGR95-121(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC EC=5.5.1.4;
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000305}.
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DR EMBL; U38920; AAA91164.1; -; mRNA.
DR PIR; T10964; T10964.
DR AlphaFoldDB; Q41107; -.
DR SMR; Q41107; -.
DR UniPathway; UPA00823; UER00787.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510; PTHR11510; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism.
FT CHAIN 1..511
FT /note="Inositol-3-phosphate synthase"
FT /id="PRO_0000195196"
SQ SEQUENCE 511 AA; 56527 MW; 76A9558088CA58EF CRC64;
MFIESFKVES PNVKYTENEI HSVYDYETTE VVHEKTVNGT YQWIVKPKTV KYDFKTDIRV
PKLGVMLVGL GGNNGSTLTA GVIANKEGIS WATKDKVQQA NYFGSLTQAS SIRVGSFNGE
EIYAPFKSLL PMVNPDDVVF GGWDISDMNL ADAMARARVL DIDLQKQLRP YMENIVPLPG
IFDPDFIAAN QGSRANHVIK GTKKEQVDHI IKDMREFKEK NKVDKVVVLW TANTERYSNE
VVGMNDTMED LMESVDRDEA EISPSTLYAI ACVLEGIPFI NGSPQHTFVP GLIDMAIRNN
VLIGGDDFKS GQTKMKSVLG DFLVGAGIKP TSIVSYNHLG NNDGMNLSAP QTFRSKEISK
SNVVDDMVAS NGILFEPGEH PDHVVVIKYV PYVADSKRAM DEYTSEIFMG GKNTIVMHNT
CEDSLLAAPI ILDLVLLAEL STRIQFKSEG EGKFHSFHPV ATILSYLTKA PLVPPGTPVI
NALSKQRAML ENIMRACVGL APENNMIMEF K