ID   INO1_SESIN              Reviewed;         510 AA.
AC   Q9FYV1;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
OS   Sesamum indicum (Oriental sesame) (Sesamum orientale).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Pedaliaceae; Sesamum.
OX   NCBI_TaxID=4182;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Seed;
RA   Jin U.-H., Chung C.-H.;
RT   "Characterization and functional analysis of a myo-inositol 1-phosphate
RT   synthase cDNA from sesame (Sesamum indicum L.) seeds.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AF284065; AAG01148.1; -; mRNA.
DR   RefSeq; NP_001291338.1; NM_001304409.1.
DR   AlphaFoldDB; Q9FYV1; -.
DR   SMR; Q9FYV1; -.
DR   EnsemblPlants; SIN_1004338.t; SIN_1004338.t; SIN_1004338.
DR   GeneID; 105176482; -.
DR   Gramene; SIN_1004338.t; SIN_1004338.t; SIN_1004338.
DR   KEGG; sind:105176482; -.
DR   OrthoDB; 451916at2759; -.
DR   PhylomeDB; Q9FYV1; -.
DR   UniPathway; UPA00823; UER00787.
DR   Proteomes; UP000504604; Linkage group LG13.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome.
FT   CHAIN           1..510
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195197"
SQ   SEQUENCE   510 AA;  56234 MW;  88D75376CE73401F CRC64;
     MFIESFKVES PNVKYTEGEI HSVYNYETTE LVHESRNGTY QWIVKPKTVK YEFKTDTHVP
     KLGVMLVGWG GNNGSTLTGG VIANREGISW ATKDKVQQAN YFGSLTQASS IRVGSFNGEE
     IYAPFKSLLP MVNPDDVVFG GWDISNMNLA DAMGRAKVLD IDLQKQLRPY MEHMVPLPGI
     YDPDFIAANQ GSRANNVIKG TKKEQVQQII KDMRDFKEQN KVDKVVVLWT ANTERYSNVV
     VGLNDTAESL MASVERNEAE ISPSTLYAIA CVFENVPFIN GSPQNTFVPG LIDLAIQRNS
     LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
     NVVDDMVASN GILYEPGEHP DHIVVIKYVP YVGDSKRAMD EYTSEIFMGG KSTIVLHNTC
     EDSLLAAPII LDLVLLAELS TRIQLKAEGE GKFHSFHPVA TILSYLTKAP LVPPGTPVVN
     ALSKQRAMLE NILRACVGLA PENNMILEYK