ID   INO1_SPIPO              Reviewed;         510 AA.
AC   P42803;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
GN   Name=TUR1;
OS   Spirodela polyrhiza (Giant duckweed) (Lemna polyrhiza).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Araceae; Lemnoideae; Spirodela.
OX   NCBI_TaxID=29656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8220483; DOI=10.1046/j.1365-313x.1993.04020279.x;
RA   Smart C.C., Fleming A.J.;
RT   "A plant gene with homology to D-myo-inositol-3-phosphate synthase is
RT   rapidly and spatially up-regulated during an abscisic-acid-induced
RT   morphogenic response in Spirodela polyrrhiza.";
RL   Plant J. 4:279-293(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: By abscisic acid (ABA).
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; Z11693; CAA77751.1; -; mRNA.
DR   PIR; S60302; S60302.
DR   AlphaFoldDB; P42803; -.
DR   SMR; P42803; -.
DR   UniPathway; UPA00823; UER00787.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism.
FT   CHAIN           1..510
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195198"
SQ   SEQUENCE   510 AA;  56386 MW;  2D56D3666FC5E03C CRC64;
     MFIEKFRVES PNVKYGDGEI ESVYSYETTE LVHEVRNGSY QWVVKPKSVQ YQFKTDTRVP
     RLGVMLVGWG GNNGSTLTAG VIANREGISW VTKEKVQQAN YFGSLTQSSS IRVGSFNGEE
     IYAPFKSLLP MVNPDEIVFG GWDISDMNLA DAMGRAKVLD IDLQKQLRPY MESMVPLPGI
     YNPDFIAANQ GSRANNVIKG PKKQQVQRII DDIREFKERE KVEKVVVLWT ANTERYSDLV
     VGLNDTMENL LAAVERDEAE ISPSSLYALA CIMEGVPFVN GSPQNTFVPG LIEMAIKRNS
     LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
     NVVDDMVSSN GILYEPGEHP DHVIVIKYVP YVGDSKRAMD EYTSEIFMGG KSTIILHNTC
     EDSLLAAPII LDLVLLAELS TRIQLKAEGE SKFHSFHPVA SILSYLSKAP LVPPGTPVVN
     ALSKQRAMLE NILRACVGLA PENNMILEYK