ID   INO1_TOBAC              Reviewed;         510 AA.
AC   Q9LW96;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Leaf;
RX   PubMed=10945337; DOI=10.1093/pcp/41.6.684;
RA   Hara K., Yagi M., Koizumi N., Kusano T., Sano H.;
RT   "Screening of wound-responsive genes identifies an immediate-early
RT   expressed gene encoding a highly charged protein in mechanically wounded
RT   tobacco plants.";
RL   Plant Cell Physiol. 41:684-691(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AB009881; BAA95788.1; -; mRNA.
DR   RefSeq; NP_001311846.1; NM_001324917.1.
DR   AlphaFoldDB; Q9LW96; -.
DR   SMR; Q9LW96; -.
DR   STRING; 4097.Q9LW96; -.
DR   GeneID; 107766502; -.
DR   KEGG; nta:107766502; -.
DR   UniPathway; UPA00823; UER00787.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0006021; P:inositol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome.
FT   CHAIN           1..510
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195199"
SQ   SEQUENCE   510 AA;  56369 MW;  4BA8FDDA5DBF6D4D CRC64;
     MFIENFKVES PNVKYTESEI HSVYDYQTTE LVHEEKNGTY QWTVKPKTVK YEFKTDVHVP
     KLGVMLVGWG GNNGSTLTGG VIANREGISW ATKDKVQQAN YFGSLTQAST IRVGSFNGEE
     IYAPFKSLLP MVNPDDVVFG GWDISGMNLA DAMARAKVFD IDLQKQLRPY MESMVPLPGI
     YDPDFIAANQ GSRANNVIKG TKKEQIDQII KDIREFKEKN KVDKVVVLWT ANTERYSNVV
     VGLNDTMENL FASVDRNEAE ISPSTLYAIA CILENVPFIN GSPQNTFVPG LIDLAIKRNT
     LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
     NVVDDMVSSN AILYEPGEHP DHVVVIKYVP YVGDSKRAMD EYTSEIFMGG KNTIVLHNTC
     EDSLLAAPII LDLVLLAELS TRIQLKAEGE GKFHSFHPVA TILSYLTKAP LVPPGTPVVN
     ALSKQRAMLE NILRACVGLA PENNMILEYK