ID   INO1_WHEAT              Reviewed;         510 AA.
AC   Q9S7U0;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
GN   Name=MIPS;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Biggar, cv. Fielder, and cv. Taber;
RA   Hussain A., Yan W., Bock C., Baga M., Chibbar R., Georges F.;
RT   "cDNA clone for myo-inositol 1-phosphate synthase from wheat.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF120146; AAD26330.1; -; mRNA.
DR   EMBL; AF120147; AAD26331.1; -; mRNA.
DR   EMBL; AF120148; AAD26332.1; -; mRNA.
DR   AlphaFoldDB; Q9S7U0; -.
DR   SMR; Q9S7U0; -.
DR   STRING; 4565.Traes_4DL_54A769EAC.1; -.
DR   PRIDE; Q9S7U0; -.
DR   eggNOG; KOG0693; Eukaryota.
DR   BRENDA; 5.5.1.4; 6500.
DR   UniPathway; UPA00823; UER00787.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; Q9S7U0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IBA:GO_Central.
DR   GO; GO:0006021; P:inositol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome.
FT   CHAIN           1..510
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195200"
SQ   SEQUENCE   510 AA;  56294 MW;  4977D959C4456C37 CRC64;
     MFIESFKVES PNVKYTENEI HSVYDYETTE VVHENRNGTY QWVVKPKTVK YDFKTDTRVP
     KLGVMLVGWG GNNGSTLTAG VIANKEGISW ATKDKVQQAN YFGSLTQASS IRVGSYNGEE
     IYAPFKSLLP MVNPDDVVFG GWDISDMNLA DAMARARVLD IDLQKQLRPY MEHMVPLPGI
     YDPDFIAANQ GSRANSVIKG TKKEQVDQII KDMREFKEKN KVDKLVVLWT ANTERYSDVV
     VGLNDTMENL LASVEKNESE ISPSTLYAIA CVLEGIPFIN GSPQNTFVPG LIELAISKNC
     LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
     NVVDDMVASN GILFEPGEHP DHVVVIKYVP YVGDSKRAMD EYTSEIFMGG KNTIVMHNTC
     EDSLLAAPII LDLVLLAELS TRIQFKAEGE GKFHSFHPVA TILSYLTKAP LVPAGTPVVN
     ALSKQRAMLE NILRACVGLA PENNMILEYK