ID   INP2_KLULA              Reviewed;         666 AA.
AC   Q6CPW5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Inheritance of peroxisomes protein 2;
GN   Name=INP2; OrderedLocusNames=KLLA0E01694g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for peroxisome inheritance. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the INP2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382125; CAG99111.1; -; Genomic_DNA.
DR   RefSeq; XP_454024.1; XM_454024.1.
DR   AlphaFoldDB; Q6CPW5; -.
DR   STRING; 28985.XP_454024.1; -.
DR   EnsemblFungi; CAG99111; CAG99111; KLLA0_E01695g.
DR   GeneID; 2893907; -.
DR   KEGG; kla:KLLA0_E01695g; -.
DR   eggNOG; ENOG502QR0E; Eukaryota.
DR   HOGENOM; CLU_024345_0_0_1; -.
DR   InParanoid; Q6CPW5; -.
DR   OMA; YCELYNI; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR   GO; GO:0017022; F:myosin binding; IEA:InterPro.
DR   GO; GO:0045033; P:peroxisome inheritance; IEA:InterPro.
DR   InterPro; IPR026235; INP2.
DR   InterPro; IPR026859; Myosin-bd.
DR   Pfam; PF12632; Vezatin; 1.
DR   PRINTS; PR02104; INPROXISOME2.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Peroxisome; Receptor; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..666
FT                   /note="Inheritance of peroxisomes protein 2"
FT                   /id="PRO_0000308734"
FT   TRANSMEM        214..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          562..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        374
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        582
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        604
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   666 AA;  77167 MW;  BF957F80E3D73C0E CRC64;
     MDIFQAVPLH LQIPRIEIPK MASAASTPST MSSSQTWSSS RPQVPISYQQ LRKLSEWGIE
     ALKDTSPTVV GQDRFESQEI LIDNDYRTDF LNSHEEDSRW SKQVDLIMKQ LPYGDLDAFV
     DEFHYEIISS QLLTSSIASH HQLFTVQKSI LNFNKENTLS IHNAEGKTIP TKYGQLLISG
     KKFYLQRTIP YMFTILTARK AFRKMLYKRH LPRSSLMSLL MIAVYLALQQ EYFHAKYSKY
     TALLNLRQMN AALQSVDKLI YRYHLTYKEL TIYKPIALTE NRGLRSDEAR TLTLLTDVLT
     CTVDQLFHKL NIASSNILPV VNAVQLTDYI SIYNVDLQSL YQMIRTVESL DITQKLERLQ
     YMRKFFLCCL LSINYTDPLK KCEIALVLKR IFPGYHVEKT SDIERFQIIS KQLYTLTQGI
     SSLLPVLHHY KHLLLSVYGS TIEKEDPESK EAVITQSIYR LSELQRYLMK QDKTSTELSS
     HLIDELNGII QIWNIDYKHN SHEQLKPPKC SPRPSSQRVF SGGLNLDIVK TTSDIPVVVD
     SFPKLTSLVD VLEVDETGSD IEKEHEELVY GTENDQETAS SNDSKFSRFT DDQLRHELNQ
     RILNLSIENK KSRENLRKQK SFELMNRKIE NQKKGRPQID CKGLFNSEES IPVLFELKQF
     LNRRSD