INP2_SCHPO
ID INP2_SCHPO Reviewed; 470 AA.
AC Q9USW2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Inheritance of peroxisomes protein 2;
GN Name=inp2; ORFNames=SPBC21B10.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for peroxisome inheritance. Acts as the peroxisome-
CC specific receptor for the myosin V motor myo2 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Localizes at the barrier septum
CC and the cell tip. {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the INP2 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB57924.1; -; Genomic_DNA.
DR PIR; T39921; T39921.
DR RefSeq; NP_595681.1; NM_001021576.2.
DR AlphaFoldDB; Q9USW2; -.
DR BioGRID; 277118; 3.
DR STRING; 4896.SPBC21B10.06c.1; -.
DR MaxQB; Q9USW2; -.
DR PaxDb; Q9USW2; -.
DR EnsemblFungi; SPBC21B10.06c.1; SPBC21B10.06c.1:pep; SPBC21B10.06c.
DR GeneID; 2540592; -.
DR KEGG; spo:SPBC21B10.06c; -.
DR PomBase; SPBC21B10.06c; inp2.
DR VEuPathDB; FungiDB:SPBC21B10.06c; -.
DR HOGENOM; CLU_567610_0_0_1; -.
DR InParanoid; Q9USW2; -.
DR OMA; IQYIIYT; -.
DR PRO; PR:Q9USW2; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; ISO:PomBase.
DR GO; GO:0017022; F:myosin binding; ISM:PomBase.
DR GO; GO:0043495; F:protein-membrane adaptor activity; ISO:PomBase.
DR GO; GO:0030048; P:actin filament-based movement; ISM:PomBase.
DR GO; GO:0045033; P:peroxisome inheritance; ISO:PomBase.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Peroxisome; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..470
FT /note="Inheritance of peroxisomes protein 2"
FT /id="PRO_0000304024"
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 385
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 470 AA; 54913 MW; E4D74BC5F4729FED CRC64;
MNVDTQLSRD GLYSSLRTRY KVYISMHAFA IWHRFISFLA IYLWPCIMGS VNLNLQDREN
EYFFDSIQYI IYTSELLVGD HELQRSHHEE QPSLVYPSSS FSSTSKFWRY FAYLLSLQIV
IDFVLYKLSS AMASLHYLKF VKIIALSYIC FSSLIRICHC WTYFIRIMGL SSLNKFVNLL
HDFETTSNRV YSQICELEAN SAANRSRLMD FLPANDPLLF NLTEQNTLSY ELSGLYEKLL
PRYQLVLSRI YPYAAASNLR NLLSLYRLPN CFGKLNSFDL RKGSSTSLKR SSMYLARKEN
QDFDDQSTQI LNHIKTAYYE LTIISKQVLC CILSFPVDSF LAERSSWLIV HREVGDLSNA
LSVSMVRLVD ILKFSVESVN RNQHNTTSKP FPRIMCKENL RSLFNELHSV MMETHESISS
YIQEGDNTAM QTYAMDEYDQ VGLLLKDLLS EWDFNRALLL NLQHMHRKRK
