INP2_YEAST
ID INP2_YEAST Reviewed; 705 AA.
AC Q03824; D6VZY5;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Inheritance of peroxisomes protein 2;
GN Name=INP2; OrderedLocusNames=YMR163C; ORFNames=YM8520.12C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MYO2.
RX PubMed=16678774; DOI=10.1016/j.devcel.2006.04.012;
RA Fagarasanu A., Fagarasanu M., Eitzen G.A., Aitchison J.D.,
RA Rachubinski R.A.;
RT "The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor
RT for the myosin V motor Myo2p of Saccharomyces cerevisiae.";
RL Dev. Cell 10:587-600(2006).
CC -!- FUNCTION: Required for peroxisome inheritance. Acts as the peroxisome-
CC specific receptor for the myosin V motor MYO2.
CC {ECO:0000269|PubMed:16678774}.
CC -!- SUBUNIT: Interacts with MYO2. {ECO:0000269|PubMed:16678774}.
CC -!- INTERACTION:
CC Q03824; P19524: MYO2; NbExp=3; IntAct=EBI-27354, EBI-11659;
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:16678774}; Single-pass membrane protein
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16678774}.
CC -!- MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the INP2 family. {ECO:0000305}.
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DR EMBL; Z49705; CAA89799.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA10059.1; -; Genomic_DNA.
DR PIR; S54521; S54521.
DR RefSeq; NP_013886.1; NM_001182667.1.
DR PDB; 6IXR; X-ray; 2.85 A; B=531-543.
DR PDBsum; 6IXR; -.
DR AlphaFoldDB; Q03824; -.
DR SMR; Q03824; -.
DR BioGRID; 35340; 76.
DR DIP; DIP-1673N; -.
DR IntAct; Q03824; 5.
DR MINT; Q03824; -.
DR STRING; 4932.YMR163C; -.
DR iPTMnet; Q03824; -.
DR PaxDb; Q03824; -.
DR PRIDE; Q03824; -.
DR EnsemblFungi; YMR163C_mRNA; YMR163C; YMR163C.
DR GeneID; 855198; -.
DR KEGG; sce:YMR163C; -.
DR SGD; S000004773; INP2.
DR VEuPathDB; FungiDB:YMR163C; -.
DR eggNOG; ENOG502QR0E; Eukaryota.
DR HOGENOM; CLU_024345_0_0_1; -.
DR InParanoid; Q03824; -.
DR OMA; YCELYNI; -.
DR BioCyc; YEAST:G3O-32853-MON; -.
DR PRO; PR:Q03824; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q03824; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IDA:SGD.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IMP:SGD.
DR GO; GO:0045033; P:peroxisome inheritance; IMP:SGD.
DR InterPro; IPR026235; INP2.
DR PRINTS; PR02104; INPROXISOME2.
PE 1: Evidence at protein level;
KW 3D-structure; Glycoprotein; Membrane; Peroxisome; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..705
FT /note="Inheritance of peroxisomes protein 2"
FT /id="PRO_0000203314"
FT TRANSMEM 215..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 379
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 569
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 574
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 705 AA; 81467 MW; E4F2A4D205A98F66 CRC64;
MTTNSRPSAL QAPGLQIFSM LKSSEEDGFM SSSLTLDSDN IIGVTENNRQ EFYSTWRKPS
LLSSRSVLHE YSPTIVGSND CTFSPITVGK TTKFFNWDDI ISRIFMQQPF GVTHQFFEEF
RYSIITSHFL NDMNHYRLSL HLDQSIMNFH KSSTLLKNVP PKSVPFMATK YGKLAVAEDK
KLYFRQNFNY LSMIITSYRV LTQLKKYCRK KNSPGLKRVV ILILVAVYLS IQQEYFRRHL
ICYKTLLKVR KVLESLQQVD VMIHKYHLRF KEIKNHSFIS RVSLISIADE HSSVIKELLV
FSSDALFYKL KSIIPDIVIF SDTSELSKYC ELYGIDVPNL YYNNTTTVKD LDGKLYRLKL
LKKFMLCCLL SLDMTGNENL SNVNMRNALN KIFPDYMARV QLKKKYNPIG TFQNIVSLLR
GLHSLLSTVL VSLNDHKQIL YAFPEETSTN TGCERANVCS FSKNDKLFQA LNYLKMIENN
LLAIDIRNGI TENDRNIIED KLEELITFWK TSKICGNISR IQKVSPTNTI NHGFHLDILK
GRKSPRSSSV QGLSLERKVD FIDVAESVND SFENDTELEE YEDYDCQEEC SAGSRQNHRV
DFIGKDSCRK PDFKQLSDNE LRRKLDERIL KLAQENREGR ERLRTAKSFE LLRKAQASMS
VKFGFQKPLR DDAFLESRPL SKCKVSSEET IPFLYELKGL LGNDS
