ID   INR1L_CARAU             Reviewed;         344 AA.
AC   C8AW47;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Interferon gamma receptor 1-like {ECO:0000305};
DE   AltName: Full=Interferon gamma receptor 1-2 {ECO:0000303|PubMed:19577303};
DE   Flags: Precursor;
GN   Name=ifngr1l {ECO:0000305};
GN   Synonyms=ifngr1-2 {ECO:0000303|PubMed:19577303};
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957 {ECO:0000312|EMBL:ACV41809.1};
RN   [1] {ECO:0000312|EMBL:ACV41809.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RX   PubMed=19577303; DOI=10.1016/j.molimm.2009.06.004;
RA   Grayfer L., Belosevic M.;
RT   "Molecular characterization of novel interferon gamma receptor 1 isoforms
RT   in zebrafish (Danio rerio) and goldfish (Carassius auratus L.).";
RL   Mol. Immunol. 46:3050-3059(2009).
CC   -!- FUNCTION: Receptor which shows binding specificity for the cytokine
CC       ifng1 (interferon gamma 1). {ECO:0000269|PubMed:19577303}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19577303};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain. Also detected in spleen,
CC       heart, intestine, gill and kidney. In immune cell populations, detected
CC       at low levels in monocytes, peripheral blood leukocytes, splenocytes,
CC       neutrophils and mature macrophages. {ECO:0000269|PubMed:19577303}.
CC   -!- INDUCTION: Up-regulated in response to ifng1 (interferon gamma 1) and
CC       tnfb (TNF-alpha 2). {ECO:0000269|PubMed:19577303}.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000305}.
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DR   EMBL; GQ149698; ACV41809.1; -; mRNA.
DR   AlphaFoldDB; C8AW47; -.
DR   SMR; C8AW47; -.
DR   Ensembl; ENSCART00000099025; ENSCARP00000090122; ENSCARG00000044280.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..344
FT                   /note="Interferon gamma receptor 1-like"
FT                   /id="PRO_5002989155"
FT   TOPO_DOM        23..229
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..344
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          24..102
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000305"
FT   REGION          300..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   344 AA;  38670 MW;  B4B9AEA4E748D207 CRC64;
     MSKHAVVQFG VVYALLFPGV FGFVPSPTNV SVVCHNFVNV LYWNYSNPTE QTKFAIKVEP
     YESPSQTVDT SQTYLDISSY STDVEDDYLV LLTAHDGQEK SEDVSIRFTY SKDYFDENKH
     KYKCSLDFPA VNTSVHKDVI EVSFQHPFKL YKQEIMKEEF TYKITHDEQM VKYSCFEDED
     LCNAEVHFNQ SVAGQCVELK LEGVIAGIPS YTYSNVCVPQ PTPETDKTGI IAALIGGATV
     VLFIIMGFVW LLWRKWSNIP QMPQGLWCII SKQSHTMLLS QPEPTDICPV TSQGPLNYLT
     EEDQSVSARD DTGADPPVVS EEGMAGEDSQ GLGCSSDYDR PKFL