ID   INS17_CAEEL             Reviewed;         108 AA.
AC   G5EFH1;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Insulin-like peptide 17 {ECO:0000305|PubMed:14730154};
DE   Flags: Precursor;
GN   Name=ins-17 {ECO:0000312|WormBase:F56F3.6};
GN   Synonyms=ins-2 {ECO:0000303|PubMed:14730154};
GN   ORFNames=F56F3.6 {ECO:0000312|WormBase:F56F3.6};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=14730154; DOI=10.1271/bbb.67.2678;
RA   Kawano T., Takuwa K., Ishiguro M., Nakajima T., Kimura Y.;
RT   "Cloning and characterization of a Caenorhabditis elegans cDNA encoding a
RT   new insulin/IGF-like peptide.";
RL   Biosci. Biotechnol. Biochem. 67:2678-2682(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=23132577; DOI=10.1271/bbb.120540;
RA   Matsunaga Y., Nakajima K., Gengyo-Ando K., Mitani S., Iwasaki T.,
RA   Kawano T.;
RT   "A Caenorhabditis elegans insulin-like peptide, INS-17: its physiological
RT   function and expression pattern.";
RL   Biosci. Biotechnol. Biochem. 76:2168-2172(2012).
CC   -!- FUNCTION: Involved in the regulation of the larval diapause.
CC       {ECO:0000269|PubMed:23132577}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in head neurons and the uterus.
CC       {ECO:0000269|PubMed:23132577}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during larval and adult stages with the
CC       highest expression during the L2 stage of larval development
CC       (PubMed:14730154). Expressed in head neurons at pre-dauer, dauer and
CC       post-dauer larval stages (PubMed:23132577). During the dauer stage,
CC       also expressed in tail neurons, amphid neurons, the ventral nerve cord
CC       and AVG interneurons (PubMed:23132577). {ECO:0000269|PubMed:14730154,
CC       ECO:0000269|PubMed:23132577}.
CC   -!- DISRUPTION PHENOTYPE: 33% reduction in the larval diapause in the
CC       presence of dauer pheromone compared to wild-type.
CC       {ECO:0000269|PubMed:23132577}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000255}.
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DR   EMBL; AB009658; BAA82662.1; -; mRNA.
DR   EMBL; BX284603; CAA83603.1; -; Genomic_DNA.
DR   PIR; S43582; S43582.
DR   RefSeq; NP_497911.1; NM_065510.4.
DR   AlphaFoldDB; G5EFH1; -.
DR   IntAct; G5EFH1; 1.
DR   STRING; 6239.F56F3.6; -.
DR   EPD; G5EFH1; -.
DR   PaxDb; G5EFH1; -.
DR   PeptideAtlas; G5EFH1; -.
DR   EnsemblMetazoa; F56F3.6.1; F56F3.6.1; WBGene00002100.
DR   GeneID; 175585; -.
DR   KEGG; cel:CELE_F56F3.6; -.
DR   CTD; 175585; -.
DR   WormBase; F56F3.6; CE00681; WBGene00002100; ins-17.
DR   eggNOG; ENOG502THVF; Eukaryota.
DR   HOGENOM; CLU_2252501_0_0_1; -.
DR   InParanoid; G5EFH1; -.
DR   OMA; DIFAICN; -.
DR   OrthoDB; 1541896at2759; -.
DR   PRO; PR:G5EFH1; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00002100; Expressed in larva and 3 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0040024; P:dauer larval development; IGI:UniProtKB.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..108
FT                   /note="Insulin-like peptide 17"
FT                   /id="PRO_5007661282"
SQ   SEQUENCE   108 AA;  11732 MW;  BEF48CA03D696EE3 CRC64;
     MFSTRGVLLL LSLMAAVAAF GLFSRPAPIT RDTIRPPRAK HGSLKLCPPG GASFLDAFNL
     ICPMRRRRRS VSENYNDGGG SLLGRTMNMC CETGCEFTDI FAICNPFG