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INS1_SCHPO
ID   INS1_SCHPO              Reviewed;         281 AA.
AC   Q9Y7R5;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=INSIG family protein;
GN   Name=ins1; ORFNames=SPCC306.05c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the INSIG family. {ECO:0000305}.
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DR   EMBL; CU329672; CAB41653.1; -; Genomic_DNA.
DR   PIR; T41283; T41283.
DR   RefSeq; NP_587813.1; NM_001022806.2.
DR   AlphaFoldDB; Q9Y7R5; -.
DR   SMR; Q9Y7R5; -.
DR   BioGRID; 275939; 12.
DR   STRING; 4896.SPCC306.05c.1; -.
DR   iPTMnet; Q9Y7R5; -.
DR   MaxQB; Q9Y7R5; -.
DR   PaxDb; Q9Y7R5; -.
DR   PRIDE; Q9Y7R5; -.
DR   EnsemblFungi; SPCC306.05c.1; SPCC306.05c.1:pep; SPCC306.05c.
DR   GeneID; 2539373; -.
DR   KEGG; spo:SPCC306.05c; -.
DR   PomBase; SPCC306.05c; ins1.
DR   VEuPathDB; FungiDB:SPCC306.05c; -.
DR   eggNOG; KOG4363; Eukaryota.
DR   HOGENOM; CLU_963648_0_0_1; -.
DR   InParanoid; Q9Y7R5; -.
DR   OMA; WIPMILF; -.
DR   PhylomeDB; Q9Y7R5; -.
DR   PRO; PR:Q9Y7R5; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0010895; P:negative regulation of ergosterol biosynthetic process; IDA:PomBase.
DR   GO; GO:2001211; P:negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway; IMP:PomBase.
DR   GO; GO:0016126; P:sterol biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR025929; INSIG_fam.
DR   PANTHER; PTHR15301; PTHR15301; 1.
DR   Pfam; PF07281; INSIG; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..281
FT                   /note="INSIG family protein"
FT                   /id="PRO_0000339168"
FT   TOPO_DOM        1..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        94..120
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250|UniProtKB:A1T557"
FT   TOPO_DOM        121..134
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        135..159
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250|UniProtKB:A1T557"
FT   TOPO_DOM        160..170
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        171..186
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250|UniProtKB:A1T557"
FT   TOPO_DOM        187..189
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        190..215
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250|UniProtKB:A1T557"
FT   TOPO_DOM        216..221
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        222..256
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250|UniProtKB:A1T557"
FT   TOPO_DOM        257..260
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        261..281
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   281 AA;  31881 MW;  3E2E89F2313D4906 CRC64;
     MSRKEIYEPR PRYPDGYNGN RAVKKSLSVL SLDNMKSTLS GLFAPLKLDE EQAEDDESLS
     SYEDYASRQI DDDLKKQRKK GITFIDYSSL ITFFCKLCVI FGLGFVFTYL AEQIVQDAKL
     PLLTVNLKSW KFEPPWPAIF GFVAVILGLS YRRMDTKYPL GAAPLRPSQS SKWQWISRYL
     AAFATLLLSM KKLLFISNSH SIVALVASSA SIWYIFDRSR NGIILSTITS VLGSILYYNL
     VDTSKIELNG VEFPEIQFRL WIPMILFSAS TIVGNAGRLL F
 
 
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