ID   INSA2_ECOLX             Reviewed;          91 AA.
AC   P0CF06; P03827; P0ADH0; P0C651; P0C653; Q2EER2; Q2MCF5; Q2MCH2; Q933I5;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Insertion element IS1 protein InsA;
OS   Escherichia coli.
OG   Plasmid IncFII R100 (NR1), Plasmid p1658/97, and Plasmid pC15-1a.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=IncFII R100 (NR1);
RX   PubMed=273224; DOI=10.1073/pnas.75.2.615;
RA   Ohtsubo H., Ohtsubo E.;
RT   "Nucleotide sequence of an insertion element, IS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 75:615-619(1978).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N00-0666; PLASMID=pC15-1a;
RX   PubMed=15388431; DOI=10.1128/aac.48.10.3758-3764.2004;
RA   Boyd D.A., Tyler S., Christianson S., McGeer A., Muller M.P., Willey B.M.,
RA   Bryce E., Gardam M., Nordmann P., Mulvey M.R.;
RT   "Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-
RT   15 extended-spectrum beta-lactamase involved in an outbreak in long-term-
RT   care facilities in Toronto, Canada.";
RL   Antimicrob. Agents Chemother. 48:3758-3764(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=IncFII R100 (NR1);
RX   PubMed=16820486; DOI=10.1128/aem.00354-06;
RA   Williams L.E., Detter C., Barry K., Lapidus A., Summers A.O.;
RT   "Facile recovery of individual high-molecular-weight, low-copy-number
RT   natural plasmids for genomic sequencing.";
RL   Appl. Environ. Microbiol. 72:4899-4906(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1658/97; PLASMID=p1658/97;
RX   PubMed=17220406; DOI=10.1128/aac.00772-06;
RA   Zienkiewicz M., Kern-Zdanowicz I., Golebiewski M., Zylinska J.,
RA   Mieczkowski P., Gniadkowski M., Bardowski J., Ceglowski P.;
RT   "Mosaic structure of p1658/97, a 125-kilobase plasmid harboring an active
RT   amplicon with the extended-spectrum beta-lactamase gene blaSHV-5.";
RL   Antimicrob. Agents Chemother. 51:1164-1171(2007).
CC   -!- FUNCTION: Absolutely required for transposition of IS1.
CC   -!- SIMILARITY: Belongs to the IS1 elements InsA family. {ECO:0000305}.
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DR   EMBL; V00609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; J01730; AAA92258.1; -; Genomic_DNA.
DR   EMBL; AF550679; AAO49560.1; -; Genomic_DNA.
DR   EMBL; DQ364638; ABD59967.1; -; Genomic_DNA.
DR   EMBL; DQ364638; ABD60065.1; -; Genomic_DNA.
DR   EMBL; AF550679; AAO49626.1; -; Genomic_DNA.
DR   EMBL; AY458016; AAR25118.1; -; Genomic_DNA.
DR   RefSeq; NP_862965.1; NC_004998.1.
DR   RefSeq; NP_863031.1; NC_004998.1.
DR   RefSeq; NP_957637.1; NC_005327.1.
DR   RefSeq; WP_000179210.1; NZ_PGKW01000165.1.
DR   RefSeq; YP_001096420.1; NC_009133.1.
DR   RefSeq; YP_001096518.1; NC_009133.1.
DR   RefSeq; YP_001816581.1; NC_010558.1.
DR   RefSeq; YP_001816635.1; NC_010558.1.
DR   RefSeq; YP_002527566.1; NC_011964.1.
DR   RefSeq; YP_003108318.1; NC_013122.1.
DR   RefSeq; YP_006953891.1; NC_019090.1.
DR   RefSeq; YP_006954228.1; NC_019095.1.
DR   RefSeq; YP_006990704.1; NC_019424.1.
DR   RefSeq; YP_007447506.1; NC_020278.2.
DR   RefSeq; YP_009071497.1; NC_025183.1.
DR   AlphaFoldDB; P0CF06; -.
DR   eggNOG; COG1662; Bacteria.
DR   eggNOG; COG3677; Bacteria.
DR   OMA; ASITIHC; -.
DR   OrthoDB; 1853786at2; -.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:InterPro.
DR   InterPro; IPR024431; InsA_HTH_dom.
DR   InterPro; IPR003220; InsA_N_dom.
DR   Pfam; PF12759; HTH_Tnp_IS1; 1.
DR   Pfam; PF03811; Zn_Tnp_IS1; 1.
PE   3: Inferred from homology;
KW   DNA recombination; Plasmid; Transposable element; Transposition.
FT   CHAIN           1..91
FT                   /note="Insertion element IS1 protein InsA"
FT                   /id="PRO_0000316160"
SQ   SEQUENCE   91 AA;  9902 MW;  8249502B66B91FC5 CRC64;
     MASVSISCPS CSATDGVVRN GKSTAGHQRY LCSHCRKTWQ LQFTYTASQP GTHQKIIDMA
     MNGVGCRATA RIMGVGLNTI FRHLKNSGRS R