ID   INSD1_ECOLI             Reviewed;         301 AA.
AC   P0CF53; P0C5W4; P19777; P76167; P76916; P77033; Q79EJ0;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transposase InsD for insertion element IS2A;
GN   Name=insD1; OrderedLocusNames=b0361, JW0352;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence IS2.
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DR   EMBL; U73857; AAB18085.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73464.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76142.1; -; Genomic_DNA.
DR   PIR; A64764; C65092.
DR   RefSeq; NP_061399.1; NC_002483.1.
DR   RefSeq; NP_414895.1; NC_000913.3.
DR   RefSeq; NP_415920.1; NC_000913.3.
DR   RefSeq; NP_416500.1; NC_000913.3.
DR   RefSeq; NP_417337.1; NC_000913.3.
DR   RefSeq; NP_417517.1; NC_000913.3.
DR   RefSeq; NP_418693.1; NC_000913.3.
DR   RefSeq; WP_000376502.1; NC_002483.1.
DR   RefSeq; YP_424823.1; NC_007635.1.
DR   AlphaFoldDB; P0CF53; -.
DR   STRING; 511145.b0361; -.
DR   PaxDb; P0CF53; -.
DR   PRIDE; P0CF53; -.
DR   EnsemblBacteria; AAC73464; AAC73464; b0361.
DR   EnsemblBacteria; BAE76142; BAE76142; BAE76142.
DR   GeneID; 945203; -.
DR   GeneID; 945952; -.
DR   GeneID; 946403; -.
DR   GeneID; 947346; -.
DR   GeneID; 947517; -.
DR   GeneID; 948779; -.
DR   KEGG; ecj:JW0352; -.
DR   KEGG; eco:b0361; -.
DR   KEGG; eco:b1402; -.
DR   KEGG; eco:b1996; -.
DR   KEGG; eco:b2860; -.
DR   KEGG; eco:b3045; -.
DR   KEGG; eco:b4273; -.
DR   EchoBASE; EB4752; -.
DR   eggNOG; COG2801; Bacteria.
DR   HOGENOM; CLU_052819_0_0_6; -.
DR   InParanoid; P0CF53; -.
DR   OMA; PRRTMYY; -.
DR   PhylomeDB; P0CF53; -.
DR   BioCyc; EcoCyc:G7480-MON; -.
DR   PRO; PR:P0CF53; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR025948; HTH-like_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13276; HTH_21; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   DNA recombination; DNA-binding; Reference proteome; Transposable element;
KW   Transposition.
FT   CHAIN           1..301
FT                   /note="Transposase InsD for insertion element IS2A"
FT                   /id="PRO_0000075411"
FT   DOMAIN          106..289
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
SQ   SEQUENCE   301 AA;  34398 MW;  9D6E3EB8FA7E2BA5 CRC64;
     MDSARALIAR GWGVSLVSRC LRVSRAQLHV ILRRTDDWMD GRRSRHTDDT DVLLRIHHVI
     GELPTYGYRR VWALLRRQAE LDGMPAINAK RVYRIMRQNA LLLERKPAVP PSKRAHTGRV
     AVKESNQRWC SDGFEFCCDN GERLRVTFAL DCCDREALHW AVTTGGFNSE TVQDVMLGAV
     ERRFGNDLPS SPVEWLTDNG SCYRANETRQ FARMLGLEPK NTAVRSPESN GIAESFVKTI
     KRDYISIMPK PDGLTAAKNL AEAFEHYNEW HPHSALGYRS PREYLRQRAC NGLSDNRCLE
     I