ID   INSD4_ECOLI             Reviewed;         301 AA.
AC   P0CF56; P0C5W4; P19777; P76167; P76916; P77033; Q79EJ0;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Transposase InsD for insertion element IS2H;
GN   Name=insD4; OrderedLocusNames=b2860, JW2826;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence IS2.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U28375; AAA83042.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC75899.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76927.1; -; Genomic_DNA.
DR   PIR; A64764; C65092.
DR   RefSeq; NP_061399.1; NC_002483.1.
DR   RefSeq; NP_414895.1; NC_000913.3.
DR   RefSeq; NP_415920.1; NC_000913.3.
DR   RefSeq; NP_416500.1; NC_000913.3.
DR   RefSeq; NP_417337.1; NC_000913.3.
DR   RefSeq; NP_417517.1; NC_000913.3.
DR   RefSeq; NP_418693.1; NC_000913.3.
DR   RefSeq; WP_000376502.1; NC_002483.1.
DR   RefSeq; YP_424823.1; NC_007635.1.
DR   AlphaFoldDB; P0CF56; -.
DR   EnsemblBacteria; AAC75899; AAC75899; b2860.
DR   EnsemblBacteria; BAE76927; BAE76927; BAE76927.
DR   GeneID; 945203; -.
DR   GeneID; 945952; -.
DR   GeneID; 946403; -.
DR   GeneID; 947346; -.
DR   GeneID; 947517; -.
DR   GeneID; 948779; -.
DR   KEGG; ecj:JW2826; -.
DR   KEGG; eco:b0361; -.
DR   KEGG; eco:b1402; -.
DR   KEGG; eco:b1996; -.
DR   KEGG; eco:b2860; -.
DR   KEGG; eco:b3045; -.
DR   KEGG; eco:b4273; -.
DR   EchoBASE; EB4737; -.
DR   HOGENOM; CLU_052819_0_0_6; -.
DR   InParanoid; P0CF56; -.
DR   OMA; MRDHEIS; -.
DR   PhylomeDB; P0CF56; -.
DR   BioCyc; EcoCyc:MON0-4448; -.
DR   PRO; PR:P0CF56; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR025948; HTH-like_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13276; HTH_21; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   DNA recombination; DNA-binding; Reference proteome; Transposable element;
KW   Transposition.
FT   CHAIN           1..301
FT                   /note="Transposase InsD for insertion element IS2H"
FT                   /id="PRO_0000393575"
FT   DOMAIN          106..289
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
SQ   SEQUENCE   301 AA;  34398 MW;  9D6E3EB8FA7E2BA5 CRC64;
     MDSARALIAR GWGVSLVSRC LRVSRAQLHV ILRRTDDWMD GRRSRHTDDT DVLLRIHHVI
     GELPTYGYRR VWALLRRQAE LDGMPAINAK RVYRIMRQNA LLLERKPAVP PSKRAHTGRV
     AVKESNQRWC SDGFEFCCDN GERLRVTFAL DCCDREALHW AVTTGGFNSE TVQDVMLGAV
     ERRFGNDLPS SPVEWLTDNG SCYRANETRQ FARMLGLEPK NTAVRSPESN GIAESFVKTI
     KRDYISIMPK PDGLTAAKNL AEAFEHYNEW HPHSALGYRS PREYLRQRAC NGLSDNRCLE
     I