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INSL1_DROME
ID   INSL1_DROME             Reviewed;         154 AA.
AC   Q9VT50;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Probable insulin-like peptide 1;
DE            Short=dILP1;
DE   AltName: Full=Insulin-related peptide 1;
DE   Contains:
DE     RecName: Full=Probable insulin-like peptide 1 A chain;
DE   Contains:
DE     RecName: Full=Probable insulin-like peptide 1 B chain;
DE   Flags: Precursor;
GN   Name=Ilp1; ORFNames=CG14173;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=11250149; DOI=10.1016/s0960-9822(01)00068-9;
RA   Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., Hafen E.;
RT   "An evolutionarily conserved function of the Drosophila insulin receptor
RT   and insulin-like peptides in growth control.";
RL   Curr. Biol. 11:213-221(2001).
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; AE014296; AAF50205.1; -; Genomic_DNA.
DR   RefSeq; NP_648359.1; NM_140102.2.
DR   AlphaFoldDB; Q9VT50; -.
DR   BioGRID; 64537; 2.
DR   STRING; 7227.FBpp0076057; -.
DR   PaxDb; Q9VT50; -.
DR   DNASU; 39149; -.
DR   EnsemblMetazoa; FBtr0076328; FBpp0076057; FBgn0044051.
DR   GeneID; 39149; -.
DR   KEGG; dme:Dmel_CG14173; -.
DR   CTD; 39149; -.
DR   FlyBase; FBgn0044051; Ilp1.
DR   VEuPathDB; VectorBase:FBgn0044051; -.
DR   eggNOG; ENOG502S3FQ; Eukaryota.
DR   HOGENOM; CLU_1706141_0_0_1; -.
DR   InParanoid; Q9VT50; -.
DR   OMA; GSHKLCG; -.
DR   OrthoDB; 1644517at2759; -.
DR   PhylomeDB; Q9VT50; -.
DR   Reactome; R-DME-110478; Insulin signaling pathway.
DR   SignaLink; Q9VT50; -.
DR   BioGRID-ORCS; 39149; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 39149; -.
DR   PRO; PR:Q9VT50; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0044051; Expressed in brain and 2 other tissues.
DR   ExpressionAtlas; Q9VT50; baseline and differential.
DR   Genevisible; Q9VT50; DM.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; ISS:FlyBase.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR040228; Insulin-relat-peptide_inver.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR13647; PTHR13647; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..154
FT                   /note="Probable insulin-like peptide 1"
FT                   /id="PRO_0000016185"
FT   PEPTIDE         30..69
FT                   /note="Probable insulin-like peptide 1 B chain"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016186"
FT   PROPEP          73..122
FT                   /note="Connecting peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016187"
FT   PEPTIDE         125..154
FT                   /note="Probable insulin-like peptide 1 A chain"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016188"
FT   REGION          72..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        49..138
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..151
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        137..142
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   154 AA;  16851 MW;  65E78F17EDC12041 CRC64;
     MFSQHNGAAV HGLRLQSLLI AAMLTAAMAM VTPTGSGHQL LPPGNHKLCG PALSDAMDVV
     CPHGFNTLPR KRESLLGNSD DDEDTEQEVQ DDSSMWQTLD GAGYSFSPLL TNLYGSEVLI
     KMRRHRRHLT GGVYDECCVK TCSYLELAIY CLPK
 
 
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