ID   INSL3_PANTR             Reviewed;         131 AA.
AC   Q5CZK3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Insulin-like 3;
DE   AltName: Full=Leydig insulin-like peptide;
DE            Short=Ley-I-L;
DE   AltName: Full=Relaxin-like factor;
DE   Contains:
DE     RecName: Full=Insulin-like 3 B chain;
DE   Contains:
DE     RecName: Full=Insulin-like 3 A chain;
DE   Flags: Precursor;
GN   Name=INSL3; Synonyms=RLF;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15707501; DOI=10.1186/1471-2148-5-14;
RA   Wilkinson T.N., Speed T.P., Tregear G.W., Bathgate R.A.D.;
RT   "Evolution of the relaxin-like peptide family.";
RL   BMC Evol. Biol. 5:14-14(2005).
CC   -!- FUNCTION: Seems to play a role in testicular function. May be a trophic
CC       hormone with a role in testicular descent in fetal life. Is a ligand
CC       for LGR8 receptor (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   AlphaFoldDB; Q5CZK3; -.
DR   BMRB; Q5CZK3; -.
DR   STRING; 9598.ENSPTRP00000018236; -.
DR   PaxDb; Q5CZK3; -.
DR   eggNOG; ENOG502TFQJ; Eukaryota.
DR   InParanoid; Q5CZK3; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR040113; INSL3.
DR   InterPro; IPR043387; INSL3/INSL4.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   PANTHER; PTHR10423; PTHR10423; 1.
DR   PANTHER; PTHR10423:SF6; PTHR10423:SF6; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         21..55
FT                   /note="Insulin-like 3 B chain"
FT                   /id="PRO_0000016146"
FT   PROPEP          58..104
FT                   /note="C peptide like"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016147"
FT   PEPTIDE         106..131
FT                   /note="Insulin-like 3 A chain"
FT                   /id="PRO_0000016148"
FT   DISULFID        34..116
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..129
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        115..120
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   131 AA;  14544 MW;  C560625CAB009136 CRC64;
     MDPRLPAWAL VLLGPALVFA LGPAPTPEMR EKLCGHHFVR ALVRVCGGPR WSTEARRPAA
     GGDREWLQWL ERRHLLHGLV ANSNLTLGPG LQPLPQTSHH HRHHRAAATN PARYCCLSGC
     TQQDLLTLCP Y