INSL4_PANTR
ID INSL4_PANTR Reviewed; 139 AA.
AC Q5CZK6;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Early placenta insulin-like peptide;
DE Short=EPIL;
DE AltName: Full=Insulin-like peptide 4;
DE AltName: Full=Placentin;
DE Contains:
DE RecName: Full=Early placenta insulin-like peptide B chain;
DE Contains:
DE RecName: Full=Early placenta insulin-like peptide A chain;
DE Flags: Precursor;
GN Name=INSL4;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=15707501; DOI=10.1186/1471-2148-5-14;
RA Wilkinson T.N., Speed T.P., Tregear G.W., Bathgate R.A.D.;
RT "Evolution of the relaxin-like peptide family.";
RL BMC Evol. Biol. 5:14-14(2005).
CC -!- FUNCTION: May play an important role in trophoblast development and in
CC the regulation of bone formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR RefSeq; NP_001171285.1; NM_001177814.1.
DR AlphaFoldDB; Q5CZK6; -.
DR STRING; 9598.ENSPTRP00000035497; -.
DR PaxDb; Q5CZK6; -.
DR Ensembl; ENSPTRT00000038399; ENSPTRP00000035497; ENSPTRG00000020750.
DR GeneID; 736816; -.
DR KEGG; ptr:736816; -.
DR CTD; 3641; -.
DR VGNC; VGNC:4765; INSL4.
DR eggNOG; ENOG502TJQC; Eukaryota.
DR GeneTree; ENSGT00940000154434; -.
DR HOGENOM; CLU_1864514_0_0_1; -.
DR InParanoid; Q5CZK6; -.
DR OMA; PSLFWSY; -.
DR OrthoDB; 1412291at2759; -.
DR TreeFam; TF333404; -.
DR Proteomes; UP000002277; Chromosome 9.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR023258; Placentin.
DR InterPro; IPR022421; Relaxin.
DR PANTHER; PTHR12004:SF3; PTHR12004:SF3; 1.
DR PRINTS; PR02033; PLACENTIN.
DR PRINTS; PR02004; RELAXIN.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..139
FT /note="Early placenta insulin-like peptide"
FT /id="PRO_0000016159"
FT PEPTIDE 26..58
FT /note="Early placenta insulin-like peptide B chain"
FT /id="PRO_0000016160"
FT PROPEP 59..114
FT /note="C peptide"
FT /id="PRO_0000016161"
FT PEPTIDE 115..139
FT /note="Early placenta insulin-like peptide A chain"
FT /id="PRO_0000016162"
FT DISULFID 31..125
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 43..138
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250"
FT DISULFID 124..129
FT /evidence="ECO:0000250"
SQ SEQUENCE 139 AA; 15478 MW; 1A9709490A629CE6 CRC64;
MASLFWSYLP AIWLLLSQLL RESLAAELRG CGPRFGKHLL SYCPMPEKTF TTTPGGWLLE
SGRPTEMVST SNNKDGQTLG TTSEFIPNLS PELKKPLSEG QPSLKKIILS RKKRSGRHRF
DPFCCEVICD DGTSVKLCT
