INSL6_BOVIN
ID INSL6_BOVIN Reviewed; 205 AA.
AC Q32L79;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Insulin-like peptide INSL6;
DE Short=Insulin-like peptide 6;
DE Contains:
DE RecName: Full=Insulin-like peptide INSL6 B chain;
DE Contains:
DE RecName: Full=Insulin-like peptide INSL6 A chain;
DE Flags: Precursor;
GN Name=INSL6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May have a role in sperm development and fertilization.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR EMBL; BC109721; AAI09722.1; -; mRNA.
DR RefSeq; NP_001070989.1; NM_001077521.2.
DR AlphaFoldDB; Q32L79; -.
DR STRING; 9913.ENSBTAP00000008739; -.
DR PaxDb; Q32L79; -.
DR Ensembl; ENSBTAT00000008739; ENSBTAP00000008739; ENSBTAG00000006651.
DR GeneID; 774023; -.
DR KEGG; bta:774023; -.
DR CTD; 11172; -.
DR VEuPathDB; HostDB:ENSBTAG00000006651; -.
DR VGNC; VGNC:30219; INSL6.
DR eggNOG; ENOG502RWPT; Eukaryota.
DR GeneTree; ENSGT00940000159958; -.
DR HOGENOM; CLU_1299356_0_0_1; -.
DR InParanoid; Q32L79; -.
DR OMA; SIACFPY; -.
DR OrthoDB; 1310975at2759; -.
DR TreeFam; TF343788; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000006651; Expressed in semen and 94 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR017100; Insulin-like_pep_6.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR12004:SF1; PTHR12004:SF1; 1.
DR Pfam; PF00049; Insulin; 1.
DR PIRSF; PIRSF037062; Insulin-like_peptide_6; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..205
FT /note="Insulin-like peptide INSL6"
FT /id="PRO_0000285795"
FT PEPTIDE 20..51
FT /note="Insulin-like peptide INSL6 B chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000285796"
FT PROPEP 53..166
FT /note="Connecting peptide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000285797"
FT PEPTIDE 171..199
FT /note="Insulin-like peptide INSL6 A chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000285798"
FT PROPEP 202..205
FT /evidence="ECO:0000255"
FT /id="PRO_0000285799"
FT DISULFID 30..177
FT /evidence="ECO:0000250"
FT DISULFID 42..190
FT /evidence="ECO:0000250"
FT DISULFID 176..181
FT /evidence="ECO:0000250"
SQ SEQUENCE 205 AA; 24001 MW; 412D2380B0BBA5D5 CRC64;
MPRFLYLCLG LLLVRVSREL NDISRARRLC GQHLLHEIVK LCGDVNWSHV EKEKPFTQLL
SQASEKVESF IPDRSESSQT TFPVWRRATN PVPTSASQEE AINNMKMQSL PEYQYKKANL
PFKTRQEESS SSQDISPYIH EIIEFQKKNT NKIKTLSNLF WGNHPQRKRR GYSEKCCQKG
CTKEELIIAC LPYIDYENLR KHQQL
