INSL6_DROME
ID INSL6_DROME Reviewed; 107 AA.
AC Q9W4Z4; C4XVH4;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Probable insulin-like peptide 6;
DE Short=dILP6;
DE AltName: Full=Insulin-related peptide 6;
DE Contains:
DE RecName: Full=Probable insulin-like peptide 6 A chain;
DE Contains:
DE RecName: Full=Probable insulin-like peptide 6 B chain;
DE Flags: Precursor;
GN Name=Ilp6 {ECO:0000312|FlyBase:FBgn0044047}; ORFNames=CG14049;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF45773.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF45773.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=11250149; DOI=10.1016/s0960-9822(01)00068-9;
RA Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., Hafen E.;
RT "An evolutionarily conserved function of the Drosophila insulin receptor
RT and insulin-like peptides in growth control.";
RL Curr. Biol. 11:213-221(2001).
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000250|UniProtKB:P01308}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at a low level in the larval gut.
CC {ECO:0000269|PubMed:11250149}.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000255}.
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DR EMBL; AE014298; AAF45773.1; -; Genomic_DNA.
DR EMBL; BT088778; ACR82503.1; -; mRNA.
DR RefSeq; NP_001188538.1; NM_001201609.1.
DR RefSeq; NP_001188539.1; NM_001201610.2.
DR RefSeq; NP_001259185.1; NM_001272256.1.
DR RefSeq; NP_570000.1; NM_130644.4.
DR AlphaFoldDB; Q9W4Z4; -.
DR BioGRID; 57757; 4.
DR IntAct; Q9W4Z4; 4.
DR STRING; 7227.FBpp0070390; -.
DR PaxDb; Q9W4Z4; -.
DR DNASU; 31220; -.
DR EnsemblMetazoa; FBtr0070406; FBpp0070390; FBgn0044047.
DR EnsemblMetazoa; FBtr0303997; FBpp0292966; FBgn0044047.
DR EnsemblMetazoa; FBtr0303998; FBpp0292967; FBgn0044047.
DR EnsemblMetazoa; FBtr0333731; FBpp0305878; FBgn0044047.
DR GeneID; 31220; -.
DR KEGG; dme:Dmel_CG14049; -.
DR CTD; 31220; -.
DR FlyBase; FBgn0044047; Ilp6.
DR VEuPathDB; VectorBase:FBgn0044047; -.
DR HOGENOM; CLU_2212610_0_0_1; -.
DR InParanoid; Q9W4Z4; -.
DR OMA; ETINFIC; -.
DR OrthoDB; 1644517at2759; -.
DR PhylomeDB; Q9W4Z4; -.
DR Reactome; R-DME-110478; Insulin signaling pathway.
DR SignaLink; Q9W4Z4; -.
DR BioGRID-ORCS; 31220; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31220; -.
DR PRO; PR:Q9W4Z4; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0044047; Expressed in arthropod fat body and 23 other tissues.
DR ExpressionAtlas; Q9W4Z4; baseline and differential.
DR Genevisible; Q9W4Z4; DM.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; ISS:FlyBase.
DR GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR GO; GO:0009267; P:cellular response to starvation; IMP:FlyBase.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IMP:FlyBase.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:FlyBase.
DR GO; GO:0042594; P:response to starvation; IMP:FlyBase.
DR InterPro; IPR036438; Insulin-like_sf.
DR SUPFAM; SSF56994; SSF56994; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..107
FT /note="Probable insulin-like peptide 6"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016205"
FT PEPTIDE 34..66
FT /note="Probable insulin-like peptide 6 B chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016206"
FT PROPEP 67..76
FT /note="Connecting peptide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016207"
FT PEPTIDE 82..107
FT /note="Probable insulin-like peptide 6 A chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016208"
FT DISULFID 48..91
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250|UniProtKB:P01308"
FT DISULFID 60..105
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250|UniProtKB:P01308"
FT DISULFID 90..96
FT /evidence="ECO:0000250|UniProtKB:P01308"
SQ SEQUENCE 107 AA; 11694 MW; 41B3273E50137A1C CRC64;
MVLKVPTSKV LLVLATLFAV AAMISSWMPQ VAASPLAPTE YEQRRMMCST GLSDVIQKIC
VSGTVALGDV FPNSFGKRRK RDLQNVTDLC CKSGGCTYRE LLQYCKG
