INSL6_MOUSE
ID INSL6_MOUSE Reviewed; 191 AA.
AC Q9QY05;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Insulin-like peptide INSL6;
DE Short=Insulin-like peptide 6;
DE Contains:
DE RecName: Full=Insulin-like peptide INSL6 B chain;
DE Contains:
DE RecName: Full=Insulin-like peptide INSL6 A chain;
DE Flags: Precursor;
GN Name=Insl6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FBV/N;
RX PubMed=10614671; DOI=10.1210/endo.141.1.7376;
RA Kasik J., Muglia L., Stephan D.A., Menon R.K.;
RT "Identification, chromosomal mapping, and partial characterization of mouse
RT Insl6: a new member of the insulin family.";
RL Endocrinology 141:458-461(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have a role in sperm development and fertilization.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR EMBL; AF143807; AAD30158.2; -; mRNA.
DR EMBL; BC028752; AAH28752.1; -; mRNA.
DR CCDS; CCDS29732.1; -.
DR RefSeq; NP_038782.1; NM_013754.1.
DR AlphaFoldDB; Q9QY05; -.
DR SMR; Q9QY05; -.
DR STRING; 10090.ENSMUSP00000054488; -.
DR iPTMnet; Q9QY05; -.
DR PhosphoSitePlus; Q9QY05; -.
DR PaxDb; Q9QY05; -.
DR PRIDE; Q9QY05; -.
DR ProteomicsDB; 266995; -.
DR Antibodypedia; 9538; 45 antibodies from 15 providers.
DR DNASU; 27356; -.
DR Ensembl; ENSMUST00000052380; ENSMUSP00000054488; ENSMUSG00000050957.
DR GeneID; 27356; -.
DR KEGG; mmu:27356; -.
DR UCSC; uc008hdd.1; mouse.
DR CTD; 11172; -.
DR MGI; MGI:1351595; Insl6.
DR VEuPathDB; HostDB:ENSMUSG00000050957; -.
DR eggNOG; ENOG502RWPT; Eukaryota.
DR GeneTree; ENSGT00940000154434; -.
DR HOGENOM; CLU_1299356_0_0_1; -.
DR InParanoid; Q9QY05; -.
DR OMA; SIACFPY; -.
DR OrthoDB; 1310975at2759; -.
DR PhylomeDB; Q9QY05; -.
DR TreeFam; TF343788; -.
DR BioGRID-ORCS; 27356; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Insl6; mouse.
DR PRO; PR:Q9QY05; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9QY05; protein.
DR Bgee; ENSMUSG00000050957; Expressed in seminiferous tubule of testis and 116 other tissues.
DR ExpressionAtlas; Q9QY05; baseline and differential.
DR Genevisible; Q9QY05; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IMP:MGI.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IMP:MGI.
DR GO; GO:0009566; P:fertilization; IMP:MGI.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
DR GO; GO:0008584; P:male gonad development; IMP:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
DR GO; GO:0051093; P:negative regulation of developmental process; IMP:MGI.
DR GO; GO:2000242; P:negative regulation of reproductive process; IMP:MGI.
DR GO; GO:0007286; P:spermatid development; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR017100; Insulin-like_pep_6.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR12004:SF1; PTHR12004:SF1; 1.
DR Pfam; PF00049; Insulin; 1.
DR PIRSF; PIRSF037062; Insulin-like_peptide_6; 1.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..191
FT /note="Insulin-like peptide INSL6"
FT /id="PRO_0000016177"
FT PEPTIDE 23..51
FT /note="Insulin-like peptide INSL6 B chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016178"
FT PROPEP 53..161
FT /note="Connecting peptide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016179"
FT PEPTIDE 166..191
FT /note="Insulin-like peptide INSL6 A chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016180"
FT DISULFID 33..172
FT /evidence="ECO:0000250"
FT DISULFID 45..185
FT /evidence="ECO:0000250"
FT DISULFID 171..176
FT /evidence="ECO:0000250"
SQ SEQUENCE 191 AA; 22215 MW; B47FFE245F031190 CRC64;
MKQLCCSCLL WLGLLLTPFS REEEEESRPR KLCGRHLLIE VIKLCGQSDW SRFEMEEQSP
MTQFFPHYSR KGKAFNPHPS SSAWRRFTNP VPAGVSQKKG THTWEPQSLP DYQFEKTELL
PKARVFSYHS GKPYVKSVQL QKKSTNKMNT FRSLFWGNHS QRKRRGFADK CCVIGCTKEE
MAVACLPFVD F
