ID   INSL6_RAT               Reviewed;         188 AA.
AC   Q9WV41;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Insulin-like peptide INSL6;
DE            Short=Insulin-like peptide 6;
DE   Contains:
DE     RecName: Full=Insulin-like peptide INSL6 B chain;
DE   Contains:
DE     RecName: Full=Insulin-like peptide INSL6 A chain;
DE   Flags: Precursor;
GN   Name=Insl6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=10819760; DOI=10.1095/biolreprod62.6.1593;
RA   Lok S., Johnston D.S., Conklin D., Lofton-Day C.E., Adams R.L.,
RA   Jelmberg A.C., Whitmore T.E., Schrader S., Griswold M.D., Jaspers S.R.;
RT   "Identification of INSL6, a new member of the insulin family that is
RT   expressed in the testis of the human and Rat.";
RL   Biol. Reprod. 62:1593-1599(2000).
CC   -!- FUNCTION: May have a role in sperm development and fertilization.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Testis and prostate specific.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF159506; AAD40956.1; -; mRNA.
DR   RefSeq; NP_072105.1; NM_022583.1.
DR   AlphaFoldDB; Q9WV41; -.
DR   STRING; 10116.ENSRNOP00000021298; -.
DR   iPTMnet; Q9WV41; -.
DR   PhosphoSitePlus; Q9WV41; -.
DR   PaxDb; Q9WV41; -.
DR   PRIDE; Q9WV41; -.
DR   Ensembl; ENSRNOT00000021298; ENSRNOP00000021298; ENSRNOG00000015868.
DR   GeneID; 50546; -.
DR   KEGG; rno:50546; -.
DR   CTD; 11172; -.
DR   RGD; 62061; Insl6.
DR   eggNOG; ENOG502RWPT; Eukaryota.
DR   GeneTree; ENSGT00940000154434; -.
DR   HOGENOM; CLU_1299356_0_0_1; -.
DR   InParanoid; Q9WV41; -.
DR   OMA; SIACFPY; -.
DR   OrthoDB; 1310975at2759; -.
DR   PhylomeDB; Q9WV41; -.
DR   TreeFam; TF343788; -.
DR   PRO; PR:Q9WV41; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000015868; Expressed in testis and 6 other tissues.
DR   Genevisible; Q9WV41; RN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0009566; P:fertilization; ISO:RGD.
DR   GO; GO:0030317; P:flagellated sperm motility; ISO:RGD.
DR   GO; GO:0008584; P:male gonad development; ISO:RGD.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0007286; P:spermatid development; ISO:RGD.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR017100; Insulin-like_pep_6.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   PANTHER; PTHR12004:SF1; PTHR12004:SF1; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PIRSF; PIRSF037062; Insulin-like_peptide_6; 1.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..188
FT                   /note="Insulin-like peptide INSL6"
FT                   /id="PRO_0000016181"
FT   PEPTIDE         23..51
FT                   /note="Insulin-like peptide INSL6 B chain"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016182"
FT   PROPEP          53..158
FT                   /note="Connecting peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016183"
FT   PEPTIDE         163..188
FT                   /note="Insulin-like peptide INSL6 A chain"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000016184"
FT   DISULFID        33..169
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..182
FT                   /evidence="ECO:0000250"
FT   DISULFID        168..173
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   188 AA;  21442 MW;  50212AB3CE9982B3 CRC64;
     MKQLCCSCLL WLGLLLAPFS QEQEEVTSPT KLCGRDLLVE VIKLCGQNDW SRFSMEEQSP
     MTELVPQYTR KVKTFNPHRS SSSWGRFTNP GVSQKKATHT WESQSLPNYQ LKKEELLPKT
     GVHSYHGGKP YVKSVKFQKK NTDKMSTFSG LFWGNHPQRK RRGFADKCCA IGCSKEELAV
     ACLPFVDF