INSL7_DROME
ID INSL7_DROME Reviewed; 159 AA.
AC Q9W4Q9;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Probable insulin-like peptide 7;
DE Short=dILP7;
DE AltName: Full=Insulin-related peptide 7;
DE Contains:
DE RecName: Full=Probable insulin-like peptide 7 A chain;
DE Contains:
DE RecName: Full=Probable insulin-like peptide 7 B chain;
DE Flags: Precursor;
GN Name=Ilp7 {ECO:0000312|FlyBase:FBgn0044046}; ORFNames=CG13317;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF45885.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF45885.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP IDENTIFICATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=11250149; DOI=10.1016/s0960-9822(01)00068-9;
RA Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., Hafen E.;
RT "An evolutionarily conserved function of the Drosophila insulin receptor
RT and insulin-like peptides in growth control.";
RL Curr. Biol. 11:213-221(2001).
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000250|UniProtKB:P01308}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Broadly expressed at a low level throughout the
CC embryo, except the yolk. Expressed at a moderate level in the embryonic
CC midgut. Larval expression is restricted to ten cells of the ventral
CC nerve cord - in four pairs of centrally located cells in the most
CC posterior abdominal segments and in one pair of dorsally located cells
CC in the A1 or A2 segments. {ECO:0000269|PubMed:11250149}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the embryo and larva.
CC {ECO:0000269|PubMed:11250149}.
CC -!- SIMILARITY: Belongs to the insulin family. {ECO:0000255}.
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DR EMBL; AE014298; AAF45885.2; -; Genomic_DNA.
DR RefSeq; NP_570070.1; NM_130714.2.
DR AlphaFoldDB; Q9W4Q9; -.
DR BioGRID; 57850; 4.
DR STRING; 7227.FBpp0070552; -.
DR PaxDb; Q9W4Q9; -.
DR EnsemblMetazoa; FBtr0070577; FBpp0070552; FBgn0044046.
DR GeneID; 31328; -.
DR KEGG; dme:Dmel_CG13317; -.
DR CTD; 31328; -.
DR FlyBase; FBgn0044046; Ilp7.
DR VEuPathDB; VectorBase:FBgn0044046; -.
DR eggNOG; ENOG502S96B; Eukaryota.
DR HOGENOM; CLU_138138_0_0_1; -.
DR InParanoid; Q9W4Q9; -.
DR OMA; TGCTWEE; -.
DR OrthoDB; 1409364at2759; -.
DR PhylomeDB; Q9W4Q9; -.
DR Reactome; R-DME-110478; Insulin signaling pathway.
DR SignaLink; Q9W4Q9; -.
DR BioGRID-ORCS; 31328; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31328; -.
DR PRO; PR:Q9W4Q9; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0044046; Expressed in neurosecretory neuron and 8 other tissues.
DR ExpressionAtlas; Q9W4Q9; baseline and differential.
DR Genevisible; Q9W4Q9; DM.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; ISS:FlyBase.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR Pfam; PF00049; Insulin; 1.
DR SUPFAM; SSF56994; SSF56994; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..159
FT /note="Probable insulin-like peptide 7"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016209"
FT PEPTIDE 32..83
FT /note="Probable insulin-like peptide 7 B chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016210"
FT PROPEP 90..121
FT /note="Connecting peptide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016211"
FT PEPTIDE 124..159
FT /note="Probable insulin-like peptide 7 A chain"
FT /evidence="ECO:0000255"
FT /id="PRO_0000016212"
FT DISULFID 63..136
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250|UniProtKB:P01308"
FT DISULFID 75..150
FT /note="Interchain (between B and A chains)"
FT /evidence="ECO:0000250|UniProtKB:P01308"
FT DISULFID 135..141
FT /evidence="ECO:0000250|UniProtKB:P01308"
SQ SEQUENCE 159 AA; 18821 MW; F4A033C82D74DF99 CRC64;
MTRMIIQNSG SWTLCGAVLL FVLPLIPTPE ALQHTEEGLE MLFRERSQSD WENVWHQETH
SRCRDKLVRQ LYWACEKDIY RLTRRNKKRT GNDEAWIKKT TTEPDGSTWL HVNYANMFLR
SRRSDGNTPS ISNECCTKAG CTWEEYAEYC PSNKRRNHY
