ID   INSM1_XENTR             Reviewed;         441 AA.
AC   A4IHR5; Q0VA44;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Insulinoma-associated protein 1;
DE   AltName: Full=Zinc finger protein IA-1;
GN   Name=insm1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional regulator. Plays a role in
CC       noradrenergic neuron, pancreatic and gastrointestinal endocrine cells
CC       differentiation during embryonic development (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q63ZV0}.
CC   -!- SIMILARITY: Belongs to the INSM1 family. {ECO:0000305}.
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DR   EMBL; AAMC01092729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC121257; AAI21258.1; -; mRNA.
DR   EMBL; BC135650; AAI35651.1; -; mRNA.
DR   RefSeq; NP_001076827.1; NM_001083358.1.
DR   AlphaFoldDB; A4IHR5; -.
DR   DNASU; 779614; -.
DR   GeneID; 779614; -.
DR   KEGG; xtr:779614; -.
DR   CTD; 3642; -.
DR   Xenbase; XB-GENE-993149; insm1.
DR   OrthoDB; 1306883at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000040150; Expressed in neurula embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0017053; C:transcription repressor complex; ISS:UniProtKB.
DR   GO; GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0031018; P:endocrine pancreas development; ISS:UniProtKB.
DR   GO; GO:0035987; P:endodermal cell differentiation; ISS:UniProtKB.
DR   GO; GO:0048732; P:gland development; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0003310; P:pancreatic A cell differentiation; ISS:UniProtKB.
DR   GO; GO:0010564; P:regulation of cell cycle process; IBA:GO_Central.
DR   GO; GO:0060290; P:transdifferentiation; ISS:UniProtKB.
DR   GO; GO:0003309; P:type B pancreatic cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR042972; INSM1/2.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR15065; PTHR15065; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..441
FT                   /note="Insulinoma-associated protein 1"
FT                   /id="PRO_0000425457"
FT   ZN_FING         258..280
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         317..339
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         372..395
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         400..423
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1..20
FT                   /note="SNAG domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q63ZV0"
FT   REGION          43..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        307
FT                   /note="A -> V (in Ref. 2; AAI35651/AAI21258)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   441 AA;  47965 MW;  B673C7D2B3368693 CRC64;
     MPKGFLVKRS RKSPPVSYRV REEEEPRGES LPGWMLLATM CPTGGAPPPC SPDRATQAPC
     CSSPRPPPAG QFGNPDTVQQ ALYSPTRPVS REQRERKYLG SPVSAESFPG LGTSSEALLY
     PPTGTANGHH GLALLPPVSS SSSVSRSQGK RPAPEPDSKP AAMPGTGPGA TSSSAPSKPP
     AAKKTKAIRK LTFEDEVTTS PVLGLKIKEG PVEPPRPRAA SSGPRPLGEF ICQLCKEEYS
     DPFSLAQHKC SRIVRVEYRC PECHKVFSCP ANLASHRRWH KPRPPVASTA QAKEEPLSDR
     DTPSPGASES GSEDGLYECP RCARKFRRQA YLRKHLLSHQ AAKEPEEPGV MMFPGEEQRA
     KSPPSLNAQE CHPCPVCGET FPGKSSQERH IRLLHSSQLY PCKYCPATFY SSPGLTRHIN
     KCHPSENRQV ILLQVPVRPA C