ID   INSR2_HUMAN             Reviewed;         200 AA.
AC   F8WCM5; Q1WM24;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Insulin, isoform 2;
DE   AltName: Full=INS-IGF2 readthrough transcript protein;
GN   Name=INS-IGF2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RX   PubMed=16531418; DOI=10.1093/hmg/ddl041;
RA   Monk D., Sanches R., Arnaud P., Apostolidou S., Hills F.A., Abu-Amero S.,
RA   Murrell A., Friess H., Reik W., Stanier P., Constancia M., Moore G.E.;
RT   "Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2
RT   isoforms show differences between mouse and human.";
RL   Hum. Mol. Genet. 15:1259-1269(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2; Synonyms=INS-IGF2;
CC         IsoId=F8WCM5-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=P01308-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Expressed in pancreas, eye and, to a lower extent,
CC       in limb. {ECO:0000269|PubMed:16531418}.
CC   -!- MISCELLANEOUS: [Isoform 2]: Based on a readthrough transcript which may
CC       produce an INS-IGF2 fusion protein.
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DR   EMBL; DQ104204; ABD93452.1; -; mRNA.
DR   EMBL; DQ104205; ABD93453.1; -; mRNA.
DR   EMBL; AC132217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS41598.1; -. [F8WCM5-1]
DR   RefSeq; NP_001035835.1; NM_001042376.2. [F8WCM5-1]
DR   AlphaFoldDB; F8WCM5; -.
DR   BMRB; F8WCM5; -.
DR   SMR; F8WCM5; -.
DR   BioGRID; 593225; 36.
DR   IntAct; F8WCM5; 1.
DR   STRING; 9606.ENSP00000380440; -.
DR   Allergome; 2121; Hom s Insulin.
DR   BioMuta; INS-IGF2; -.
DR   jPOST; F8WCM5; -.
DR   MassIVE; F8WCM5; -.
DR   PaxDb; F8WCM5; -.
DR   PeptideAtlas; F8WCM5; -.
DR   PRIDE; F8WCM5; -.
DR   Antibodypedia; 1030; 70 antibodies from 7 providers.
DR   DNASU; 723961; -.
DR   Ensembl; ENST00000356578.8; ENSP00000348986.4; ENSG00000129965.15. [F8WCM5-1]
DR   Ensembl; ENST00000397270.1; ENSP00000380440.1; ENSG00000129965.15. [F8WCM5-1]
DR   GeneID; 723961; -.
DR   KEGG; hsa:723961; -.
DR   UCSC; uc001lvm.4; human. [F8WCM5-1]
DR   CTD; 723961; -.
DR   DisGeNET; 723961; -.
DR   GeneCards; INS-IGF2; -.
DR   HGNC; HGNC:33527; INS-IGF2.
DR   HPA; ENSG00000129965; Tissue enriched (pancreas).
DR   MalaCards; INS-IGF2; -.
DR   neXtProt; NX_F8WCM5; -.
DR   OpenTargets; ENSG00000129965; -.
DR   VEuPathDB; HostDB:ENSG00000129965; -.
DR   eggNOG; ENOG502T8I0; Eukaryota.
DR   GeneTree; ENSGT00390000015440; -.
DR   HOGENOM; CLU_112503_0_0_1; -.
DR   InParanoid; F8WCM5; -.
DR   OMA; FRQRDLG; -.
DR   OrthoDB; 1452648at2759; -.
DR   PhylomeDB; F8WCM5; -.
DR   PathwayCommons; F8WCM5; -.
DR   BioGRID-ORCS; 723961; 16 hits in 1010 CRISPR screens.
DR   ChiTaRS; INS-IGF2; human.
DR   GenomeRNAi; 723961; -.
DR   Pharos; F8WCM5; Tbio.
DR   PRO; PR:F8WCM5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; F8WCM5; protein.
DR   Bgee; ENSG00000129965; Expressed in islet of Langerhans and 19 other tissues.
DR   Genevisible; F8WCM5; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   PANTHER; PTHR11454; PTHR11454; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..200
FT                   /note="Insulin, isoform 2"
FT                   /id="PRO_0000422829"
FT   REGION          148..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..178
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        144
FT                   /note="L -> P (in Ref. 1; ABD93453/ABD93452)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   200 AA;  21537 MW;  CF5F0050FBF099B2 CRC64;
     MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED
     LQASALSLSS STSTWPEGLD ATARAPPALV VTANIGQAGG SSSRQFRQRA LGTSDSPVLF
     IHCPGAAGTA QGLEYRGRRV TTELVWEEVD SSPQPQGSES LPAQPPAQPA PQPEPQQARE
     PSPEVSCCGL WPRRPQRSQN