ID   INSY1_BOVIN             Reviewed;         292 AA.
AC   A7YWL5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Inhibitory synaptic factor 1 {ECO:0000305};
DE            Short=InSyn1 {ECO:0000250|UniProtKB:Q8CD60};
GN   Name=INSYN1 {ECO:0000250|UniProtKB:Q2T9L4};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the protein machinery at the inhibitory
CC       synapses, probably acting as a scaffold. Inhibitory synapses dampen
CC       neuronal activity through postsynaptic hyperpolarization. This synaptic
CC       inhibition is fundamental for the functioning of the central nervous
CC       system, shaping and orchestrating the flow of information through
CC       neuronal networks to generate a precise neural code.
CC       {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SUBUNIT: Interacts with GPHN. {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic density
CC       {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SIMILARITY: Belongs to the INSYN1 family. {ECO:0000305}.
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DR   EMBL; BC134648; AAI34649.1; -; mRNA.
DR   RefSeq; NP_001098902.1; NM_001105432.1.
DR   AlphaFoldDB; A7YWL5; -.
DR   SMR; A7YWL5; -.
DR   STRING; 9913.ENSBTAP00000036346; -.
DR   PaxDb; A7YWL5; -.
DR   GeneID; 613490; -.
DR   KEGG; bta:613490; -.
DR   CTD; 388135; -.
DR   eggNOG; ENOG502R2SS; Eukaryota.
DR   OrthoDB; 1272531at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0060080; P:inhibitory postsynaptic potential; ISS:UniProtKB.
DR   InterPro; IPR027997; Largen/INSYN1.
DR   PANTHER; PTHR15917; PTHR15917; 1.
DR   Pfam; PF15252; DUF4589; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Synapse.
FT   CHAIN           1..292
FT                   /note="Inhibitory synaptic factor 1"
FT                   /id="PRO_0000337044"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          23..63
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        200..214
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..239
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  31695 MW;  69F6D42CB9D60B6D CRC64;
     MNIRGTPDLG QPSDDPSSGG ERERIRQRMK MVIGQLEDIL RELKEVAKEL REVVSQIDKL
     TSDFDFELEP DDWTTATVSS TSSSDKAGVG GPFDLGHLDF MTADILSDSW EFCSFLDIST
     PSDSVDCPES TRPGAGPDYQ LMNGGLPVPN GPRVETPDSS SEEAFSAGPV KGQLPQRTPG
     TRERVRFSDK VLYHALCCDD EEGDGEEEAA EEEGGLSPEP AHTEAPAGPL KPSPAPYKPR
     RSPLTGRRSG PTSVPEQTRR VTRNSSTQTV SDKSTQTVLP YTATRQKAKG KN