INSY1_DANRE
ID INSY1_DANRE Reviewed; 287 AA.
AC Q1L899;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Inhibitory synaptic factor 1 {ECO:0000250|UniProtKB:Q8CD60};
DE Short=InSyn1 {ECO:0000250|UniProtKB:Q8CD60};
GN Name=insy1 {ECO:0000250|UniProtKB:Q2T9L4}; ORFNames=si:dkey-105e17.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a component of the protein machinery at the inhibitory
CC synapses, probably acting as a scaffold.
CC {ECO:0000250|UniProtKB:Q8CD60}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000250|UniProtKB:Q8CD60}.
CC -!- SIMILARITY: Belongs to the INSYN1 family. {ECO:0000305}.
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DR EMBL; CR933843; CAK05068.1; -; Genomic_DNA.
DR EMBL; BC127579; AAI27580.1; -; mRNA.
DR EMBL; BC155798; AAI55799.1; -; mRNA.
DR RefSeq; NP_001073418.1; NM_001079949.2.
DR RefSeq; XP_005173740.1; XM_005173683.3.
DR RefSeq; XP_005173741.1; XM_005173684.3.
DR RefSeq; XP_017207376.1; XM_017351887.1.
DR AlphaFoldDB; Q1L899; -.
DR SMR; Q1L899; -.
DR STRING; 7955.ENSDARP00000119803; -.
DR PaxDb; Q1L899; -.
DR Ensembl; ENSDART00000014582; ENSDARP00000013334; ENSDARG00000026247.
DR Ensembl; ENSDART00000140352; ENSDARP00000143115; ENSDARG00000026247.
DR Ensembl; ENSDART00000143911; ENSDARP00000119803; ENSDARG00000026247.
DR Ensembl; ENSDART00000192120; ENSDARP00000145120; ENSDARG00000026247.
DR GeneID; 100003007; -.
DR KEGG; dre:100003007; -.
DR CTD; 388135; -.
DR ZFIN; ZDB-GENE-030131-8029; insyn1.
DR eggNOG; ENOG502R2SS; Eukaryota.
DR GeneTree; ENSGT00910000144204; -.
DR HOGENOM; CLU_073752_1_0_1; -.
DR InParanoid; Q1L899; -.
DR OMA; EDKSGCA; -.
DR OrthoDB; 1272531at2759; -.
DR PhylomeDB; Q1L899; -.
DR TreeFam; TF332382; -.
DR PRO; PR:Q1L899; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000026247; Expressed in brain and 4 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR GO; GO:0060080; P:inhibitory postsynaptic potential; IBA:GO_Central.
DR InterPro; IPR027997; Largen/INSYN1.
DR PANTHER; PTHR15917; PTHR15917; 1.
DR Pfam; PF15252; DUF4589; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome; Synapse.
FT CHAIN 1..287
FT /note="Inhibitory synaptic factor 1"
FT /id="PRO_0000337048"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..58
FT /evidence="ECO:0000255"
FT COMPBIAS 121..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..207
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 31765 MW; D1C8D2354B82BDBC CRC64;
MSQSRAPARE PSETPSQREQ IRSHMKMVIQ QLEGILKELK DVAHELREVV GQIDKLTSDL
ELDLDADDWT VATASSTSSS ERGLCEAFRL DFLGQDSLSD SWDFCSFLES SSRRSARDDT
KPPPTTASVY SQMNGGLPVP NGPLIITPDS SSEEASSSTH SQSQKTSRTA GTRERVRFSD
KILYHALCCD DDEDEDEDED GRDEEEDKLD TDSERSPLAG SPVPPLPELY NCREPPAGGS
HTIPRKDALN PGCRKKLLRN SSTQTVSDKS TQTLLPYVPA KHRNKDL
