INSY1_HUMAN
ID INSY1_HUMAN Reviewed; 293 AA.
AC Q2T9L4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Inhibitory synaptic factor 1 {ECO:0000305};
DE Short=InSyn1 {ECO:0000305};
GN Name=INSYN1 {ECO:0000312|HGNC:HGNC:33753}; Synonyms=C15orf59;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the protein machinery at the inhibitory
CC synapses, probably acting as a scaffold. Inhibitory synapses dampen
CC neuronal activity through postsynaptic hyperpolarization. This synaptic
CC inhibition is fundamental for the functioning of the central nervous
CC system, shaping and orchestrating the flow of information through
CC neuronal networks to generate a precise neural code.
CC {ECO:0000250|UniProtKB:Q8CD60}.
CC -!- SUBUNIT: Interacts with GPHN. {ECO:0000250|UniProtKB:Q8CD60}.
CC -!- INTERACTION:
CC Q2T9L4; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-4311436, EBI-11096309;
CC Q2T9L4; Q9UL45: BLOC1S6; NbExp=7; IntAct=EBI-4311436, EBI-465781;
CC Q2T9L4; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-4311436, EBI-10193358;
CC Q2T9L4; Q9UFG5: C19orf25; NbExp=3; IntAct=EBI-4311436, EBI-741214;
CC Q2T9L4; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-4311436, EBI-10749669;
CC Q2T9L4; O60941-5: DTNB; NbExp=3; IntAct=EBI-4311436, EBI-11984733;
CC Q2T9L4; P60520: GABARAPL2; NbExp=3; IntAct=EBI-4311436, EBI-720116;
CC Q2T9L4; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-4311436, EBI-348259;
CC Q2T9L4; Q96AL5: PBX3; NbExp=3; IntAct=EBI-4311436, EBI-741171;
CC Q2T9L4; O95295: SNAPIN; NbExp=3; IntAct=EBI-4311436, EBI-296723;
CC Q2T9L4; Q9Y3C0: WASHC3; NbExp=3; IntAct=EBI-4311436, EBI-712969;
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000250|UniProtKB:Q8CD60}.
CC -!- SIMILARITY: Belongs to the INSYN1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC111368; AAI11369.1; -; mRNA.
DR CCDS; CCDS32289.1; -.
DR RefSeq; NP_001034703.1; NM_001039614.2.
DR RefSeq; XP_005254426.1; XM_005254369.4.
DR AlphaFoldDB; Q2T9L4; -.
DR SMR; Q2T9L4; -.
DR BioGRID; 132568; 278.
DR IntAct; Q2T9L4; 14.
DR STRING; 9606.ENSP00000457205; -.
DR iPTMnet; Q2T9L4; -.
DR PhosphoSitePlus; Q2T9L4; -.
DR BioMuta; C15orf59; -.
DR DMDM; 121941727; -.
DR MassIVE; Q2T9L4; -.
DR PaxDb; Q2T9L4; -.
DR PeptideAtlas; Q2T9L4; -.
DR PRIDE; Q2T9L4; -.
DR Antibodypedia; 52382; 15 antibodies from 9 providers.
DR DNASU; 388135; -.
DR Ensembl; ENST00000569673.3; ENSP00000457205.1; ENSG00000205363.7.
DR GeneID; 388135; -.
DR KEGG; hsa:388135; -.
DR MANE-Select; ENST00000569673.3; ENSP00000457205.1; NM_001039614.3; NP_001034703.1.
DR UCSC; uc002avy.4; human.
DR CTD; 388135; -.
DR DisGeNET; 388135; -.
DR GeneCards; INSYN1; -.
DR HGNC; HGNC:33753; INSYN1.
DR HPA; ENSG00000205363; Tissue enhanced (brain, heart muscle).
DR MIM; 617128; gene.
DR neXtProt; NX_Q2T9L4; -.
DR OpenTargets; ENSG00000205363; -.
DR PharmGKB; PA162378260; -.
DR VEuPathDB; HostDB:ENSG00000205363; -.
DR eggNOG; ENOG502R2SS; Eukaryota.
DR GeneTree; ENSGT00910000144204; -.
DR HOGENOM; CLU_073752_1_0_1; -.
DR InParanoid; Q2T9L4; -.
DR OMA; EDKSGCA; -.
DR OrthoDB; 1272531at2759; -.
DR PhylomeDB; Q2T9L4; -.
DR TreeFam; TF332382; -.
DR PathwayCommons; Q2T9L4; -.
DR SignaLink; Q2T9L4; -.
DR BioGRID-ORCS; 388135; 9 hits in 1033 CRISPR screens.
DR GenomeRNAi; 388135; -.
DR Pharos; Q2T9L4; Tdark.
DR PRO; PR:Q2T9L4; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q2T9L4; protein.
DR Bgee; ENSG00000205363; Expressed in apex of heart and 146 other tissues.
DR ExpressionAtlas; Q2T9L4; baseline and differential.
DR Genevisible; Q2T9L4; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR GO; GO:0060080; P:inhibitory postsynaptic potential; ISS:UniProtKB.
DR InterPro; IPR027997; Largen/INSYN1.
DR PANTHER; PTHR15917; PTHR15917; 1.
DR Pfam; PF15252; DUF4589; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome; Synapse.
FT CHAIN 1..293
FT /note="Inhibitory synaptic factor 1"
FT /id="PRO_0000337045"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 30..63
FT /evidence="ECO:0000255"
FT COMPBIAS 240..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 31928 MW; DC3E535979396B67 CRC64;
MNIRGAPDLG QPSDDPSSGG ERERIRQRMK MVIGQLEGIL RELKEVAKEL REVVSQIDKL
TSDFDFELEP DDWTTATVSS TSSSDKAGMG GPFDLGHLDF MTADILSDSW EFCSFLDVST
PSDSVDGPES TRPGAGPDYR LMNGGTPIPN GPRVETPDSS SEEAFGAGPT VKSQLPQRTP
GTRERVRFSD KVLYHALCCD DEEGDGEQEV EEEEVGLPPE PAHTEAHAGP HKPSPAPYKS
RRSPLTSRHS GSTLAPEQTR RVTRNSSTQT VSDKSTQTVL PYTATRQKAR GKN
