ID   INSY1_RAT               Reviewed;         291 AA.
AC   B0BN13;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Inhibitory synaptic factor 1 {ECO:0000305};
DE            Short=InSyn1 {ECO:0000250|UniProtKB:Q8CD60};
GN   Name=Insyn1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the protein machinery at the inhibitory
CC       synapses, probably acting as a scaffold. Inhibitory synapses dampen
CC       neuronal activity through postsynaptic hyperpolarization. This synaptic
CC       inhibition is fundamental for the functioning of the central nervous
CC       system, shaping and orchestrating the flow of information through
CC       neuronal networks to generate a precise neural code.
CC       {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SUBUNIT: Interacts with GPHN. {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic density
CC       {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SIMILARITY: Belongs to the INSYN1 family. {ECO:0000305}.
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DR   EMBL; BC158644; AAI58645.1; -; mRNA.
DR   RefSeq; NP_001107263.1; NM_001113791.1.
DR   AlphaFoldDB; B0BN13; -.
DR   SMR; B0BN13; -.
DR   STRING; 10116.ENSRNOP00000031920; -.
DR   PaxDb; B0BN13; -.
DR   Ensembl; ENSRNOT00000116428; ENSRNOP00000090146; ENSRNOG00000068374.
DR   GeneID; 501007; -.
DR   KEGG; rno:501007; -.
DR   UCSC; RGD:1562618; rat.
DR   CTD; 388135; -.
DR   RGD; 1562618; Insyn1.
DR   eggNOG; ENOG502R2SS; Eukaryota.
DR   GeneTree; ENSGT00910000144204; -.
DR   HOGENOM; CLU_073752_1_0_1; -.
DR   InParanoid; B0BN13; -.
DR   OMA; EDKSGCA; -.
DR   OrthoDB; 1272531at2759; -.
DR   PhylomeDB; B0BN13; -.
DR   TreeFam; TF332382; -.
DR   PRO; PR:B0BN13; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000026238; Expressed in frontal cortex and 18 other tissues.
DR   Genevisible; B0BN13; RN.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR   GO; GO:0060080; P:inhibitory postsynaptic potential; ISS:UniProtKB.
DR   InterPro; IPR027997; Largen/INSYN1.
DR   PANTHER; PTHR15917; PTHR15917; 1.
DR   Pfam; PF15252; DUF4589; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Synapse.
FT   CHAIN           1..291
FT                   /note="Inhibitory synaptic factor 1"
FT                   /id="PRO_0000337047"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          30..63
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        256..282
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  31654 MW;  4FA4DEB8BB97F1BE CRC64;
     MNIRGAPDLG QPSDDPNSGG ERERIRQRMK MVIGQLEGIL RELKEVAKEL REVVSQIDKL
     TSDFDFELEP DDWTTATVSS TSSSDKAGAG GPFDLGHLDF MTADILSDSW EFCSFLDVST
     PSDSVDGPEA PRPGTGPDYQ LMNGGLPIPN GPRVETPDSS SEEAFSAGPA KGQVPQRTPG
     TRERVRFSDK VLYHALCCDD EEGDGEEVEE EEAGLAPELP RVEPHTGPLK PSPAPYKTKR
     SPLTTRRLGP TLAPEQTRRV TRNSSTQTVS DKSTQTVLPY TATKQKAKGK N