ID   INSY1_XENLA             Reviewed;         247 AA.
AC   Q5PQ25;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Inhibitory synaptic factor 1 {ECO:0000305};
DE            Short=InSyn1 {ECO:0000250|UniProtKB:Q8CD60};
GN   Name=insy1 {ECO:0000250|UniProtKB:Q2T9L4};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a component of the protein machinery at the inhibitory
CC       synapses, probably acting as a scaffold.
CC       {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic density
CC       {ECO:0000250|UniProtKB:Q8CD60}.
CC   -!- SIMILARITY: Belongs to the INSYN1 family. {ECO:0000305}.
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DR   EMBL; BC087394; AAH87394.1; -; mRNA.
DR   RefSeq; NP_001088740.1; NM_001095271.1.
DR   RefSeq; XP_018106657.1; XM_018251168.1.
DR   RefSeq; XP_018106658.1; XM_018251169.1.
DR   RefSeq; XP_018106659.1; XM_018251170.1.
DR   AlphaFoldDB; Q5PQ25; -.
DR   SMR; Q5PQ25; -.
DR   DNASU; 496004; -.
DR   GeneID; 496004; -.
DR   KEGG; xla:496004; -.
DR   CTD; 496004; -.
DR   Xenbase; XB-GENE-5931911; insyn1.L.
DR   OMA; EDKSGCA; -.
DR   OrthoDB; 1272531at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 496004; Expressed in brain and 6 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027997; Largen/INSYN1.
DR   PANTHER; PTHR15917; PTHR15917; 1.
DR   Pfam; PF15252; DUF4589; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Synapse.
FT   CHAIN           1..247
FT                   /note="Inhibitory synaptic factor 1"
FT                   /id="PRO_0000337049"
FT   REGION          69..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          30..65
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        73..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  26850 MW;  726261FCCDC330D1 CRC64;
     MCSRGVGRTT EQGIRIGRAG ERERIRGRVR AVIGQLEGIL RDLKEVAKEL KEVVEQIDRL
     TSDFEFELDT DDWTPGTVSS TSSSEKGGPL CDLGPLDFLS SDSWEFCSFL EASTPSDSGD
     GSDRPPDFRL LNGGVTPNGP DSSSEEIPIA QQKPPPSKNS GSRDRVRFSD KVLYHALCCD
     DSEDPPYGQE TPRDPPRATA PCAVMKSKPG GLTGVRKGTR NCSTQTVCDK STQTVLPYVP
     KKGKDKL