ID   INS_AMICA               Reviewed;          52 AA.
AC   P29335;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=ins;
OS   Amia calva (Bowfin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Amiiformes; Amiidae; Amia.
OX   NCBI_TaxID=7924;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2039477; DOI=10.1042/bj2760261;
RA   Conlon J.M., Youson J.H., Whittaker J.;
RT   "Structure and receptor-binding activity of insulin from a holostean fish,
RT   the bowfin (Amia calva).";
RL   Biochem. J. 276:261-264(1991).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; S15426; S15426.
DR   AlphaFoldDB; P29335; -.
DR   SMR; P29335; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 2.
DR   Pfam; PF00049; Insulin; 2.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..31
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015744"
FT   PEPTIDE         32..52
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015745"
FT   DISULFID        7..38
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        19..51
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        37..42
FT   NON_CONS        31..32
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   52 AA;  5777 MW;  A3F5955F9C263FB1 CRC64;
     AASQHLCGSH LVEALFLVCG ESGFFYNPNK SGIVEQCCLK PCTIYEMEKY CN