ID   INS_ATRSP               Reviewed;          52 AA.
AC   P09476;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=ins;
OS   Atractosteus spatula (Alligator gar) (Lepisosteus spatula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Atractosteus.
OX   NCBI_TaxID=7917;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3311873; DOI=10.1016/0016-6480(87)90192-4;
RA   Pollock H.G., Kimmel J.R., Hamilton J.W., Rouse J.B., Ebner K.E., Lance V.,
RA   Rawitch A.B.;
RT   "Isolation and structures of alligator gar (Lepisosteus spatula) insulin
RT   and pancreatic polypeptide.";
RL   Gen. Comp. Endocrinol. 67:375-382(1987).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; S09342; INGXA.
DR   AlphaFoldDB; P09476; -.
DR   SMR; P09476; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 2.
DR   Pfam; PF00049; Insulin; 2.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..31
FT                   /note="Insulin B chain"
FT                   /evidence="ECO:0000269|PubMed:3311873"
FT                   /id="PRO_0000015830"
FT   PEPTIDE         32..52
FT                   /note="Insulin A chain"
FT                   /evidence="ECO:0000269|PubMed:3311873"
FT                   /id="PRO_0000015831"
FT   DISULFID        7..38
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        19..51
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        37..42
FT   NON_CONS        31..32
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   52 AA;  5865 MW;  6D61138386AC0F10 CRC64;
     AANQHLCGSH LVEALYLVCG EKGFFYNPNK VGIVEQCCHK PCTIYELENY CN