ID   INS_CHICK               Reviewed;         107 AA.
AC   P67970; P01332; Q53YX4;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
DE   Flags: Precursor;
GN   Name=INS;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7388949; DOI=10.1016/0092-8674(80)90641-8;
RA   Perler F., Efstratiadis A., Lomedico P., Gilbert W., Kolodner R.,
RA   Dodgson J.B.;
RT   "The evolution of genes: the chicken preproinsulin gene.";
RL   Cell 20:555-566(1980).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RA   Hasegawa S., Honda K., Nata K., Yonekura H., Okamoto H., Hikami Y.;
RT   "Isolation of a cDNA encoding chicken insulin precursor.";
RL   Anim. Sci. Technol. 62:867-869(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nie Q., Fang M., Sun B., Lei M., Zhang X.;
RT   "Complete coding region of chicken preproinsulin gene.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   PROTEIN SEQUENCE OF 25-54 AND 87-107.
RX   PubMed=5949593; DOI=10.1016/0002-9343(66)90145-8;
RA   Smith L.F.;
RT   "Species variation in the amino acid sequence of insulin.";
RL   Am. J. Med. 40:662-666(1966).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; V00416; CAA23707.1; -; Genomic_DNA.
DR   EMBL; V00418; CAA23708.1; -; Genomic_DNA.
DR   EMBL; X58993; CAA41738.1; -; mRNA.
DR   EMBL; AY438372; AAR13049.1; -; Genomic_DNA.
DR   PIR; A90796; IPCH.
DR   RefSeq; NP_990553.1; NM_205222.3.
DR   AlphaFoldDB; P67970; -.
DR   SMR; P67970; -.
DR   STRING; 9031.ENSGALP00000010567; -.
DR   PaxDb; P67970; -.
DR   Ensembl; ENSGALT00000010581; ENSGALP00000010567; ENSGALG00000006552.
DR   GeneID; 396145; -.
DR   KEGG; gga:396145; -.
DR   CTD; 3630; -.
DR   VEuPathDB; HostDB:geneid_396145; -.
DR   eggNOG; ENOG502S5P5; Eukaryota.
DR   GeneTree; ENSGT00940000164327; -.
DR   HOGENOM; CLU_140421_1_0_1; -.
DR   InParanoid; P67970; -.
DR   OMA; LANQHLC; -.
DR   OrthoDB; 1644517at2759; -.
DR   PhylomeDB; P67970; -.
DR   TreeFam; TF332820; -.
DR   Reactome; R-GGA-264876; Insulin processing.
DR   Reactome; R-GGA-422085; Synthesis, secretion, and deacylation of Ghrelin.
DR   Reactome; R-GGA-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-GGA-74713; IRS activation.
DR   Reactome; R-GGA-74749; Signal attenuation.
DR   Reactome; R-GGA-74751; Insulin receptor signalling cascade.
DR   Reactome; R-GGA-74752; Signaling by Insulin receptor.
DR   Reactome; R-GGA-77387; Insulin receptor recycling.
DR   PRO; PR:P67970; -.
DR   Proteomes; UP000000539; Chromosome 5.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0008283; P:cell population proliferation; IDA:AgBase.
DR   GO; GO:0010467; P:gene expression; IDA:AgBase.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IDA:AgBase.
DR   GO; GO:0003407; P:neural retina development; TAS:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Disulfide bond; Glucose metabolism; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:5949593"
FT   PEPTIDE         25..54
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015790"
FT   PROPEP          57..84
FT                   /note="C peptide"
FT                   /id="PRO_0000015791"
FT   PEPTIDE         87..107
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015792"
FT   DISULFID        31..93
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        43..106
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        92..97
SQ   SEQUENCE   107 AA;  11981 MW;  3D43C5D82B25DCDD CRC64;
     MALWIRSLPL LALLVFSGPG TSYAAANQHL CGSHLVEALY LVCGERGFFY SPKARRDVEQ
     PLVSSPLRGE AGVLPFQQEE YEKVKRGIVE QCCHNTCSLY QLENYCN