APOC4_HUMAN
ID APOC4_HUMAN Reviewed; 127 AA.
AC P55056; B3KWY6; Q53YY8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Apolipoprotein C-IV;
DE Short=Apo-CIV;
DE Short=ApoC-IV;
DE AltName: Full=Apolipoprotein C4;
DE Flags: Precursor;
GN Name=APOC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8530039; DOI=10.1006/geno.1995.1144;
RA Allan C.M., Walker D., Segrest J.P., Taylor J.M.;
RT "Identification and characterization of a new human gene (APOC4) in the
RT apolipoprotein E, C-I, and C-II gene locus.";
RL Genomics 28:291-300(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PRO-36.
RA Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H.,
RA Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.;
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63.
RC TISSUE=Plasma;
RX PubMed=16335952; DOI=10.1021/pr0502065;
RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J.,
RA Smith R.D.;
RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT hydrazide chemistry, and mass spectrometry.";
RL J. Proteome Res. 4:2070-2080(2005).
RN [7]
RP VARIANTS PRO-36; ASP-52 AND ARG-96.
RX PubMed=10996355; DOI=10.1016/s0021-9150(99)00459-1;
RA Kamboh M.I., Aston C.E., Hamman R.F.;
RT "DNA sequence variation in human apolipoprotein C4 gene and its effect on
RT plasma lipid profile.";
RL Atherosclerosis 152:193-201(2000).
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] GLN-75.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May participate in lipoprotein metabolism.
CC -!- INTERACTION:
CC P55056; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-18302142, EBI-4290634;
CC P55056; Q92843: BCL2L2; NbExp=3; IntAct=EBI-18302142, EBI-707714;
CC P55056; Q9NR28: DIABLO; NbExp=3; IntAct=EBI-18302142, EBI-517508;
CC P55056; Q05329: GAD2; NbExp=3; IntAct=EBI-18302142, EBI-9304251;
CC P55056; Q96QA5: GSDMA; NbExp=3; IntAct=EBI-18302142, EBI-11320924;
CC P55056; P40305-1: IFI27; NbExp=3; IntAct=EBI-18302142, EBI-23832675;
CC P55056; Q6P1Q0: LETMD1; NbExp=3; IntAct=EBI-18302142, EBI-1549822;
CC P55056; Q8WWC4: MAIP1; NbExp=3; IntAct=EBI-18302142, EBI-1042937;
CC P55056; Q5TGZ0: MICOS10; NbExp=3; IntAct=EBI-18302142, EBI-12886442;
CC P55056; Q5XKP0: MICOS13; NbExp=3; IntAct=EBI-18302142, EBI-1053887;
CC P55056; Q9UMS0: NFU1; NbExp=3; IntAct=EBI-18302142, EBI-725252;
CC P55056; Q9H237-2: PORCN; NbExp=3; IntAct=EBI-18302142, EBI-18254170;
CC P55056; Q8WXG1: RSAD2; NbExp=3; IntAct=EBI-18302142, EBI-12736320;
CC P55056; Q9HC62: SENP2; NbExp=3; IntAct=EBI-18302142, EBI-714881;
CC P55056; Q5SQN1: SNAP47; NbExp=3; IntAct=EBI-18302142, EBI-10244848;
CC P55056; Q17RD7: SYT16; NbExp=3; IntAct=EBI-18302142, EBI-10238936;
CC P55056; Q96BZ9: TBC1D20; NbExp=3; IntAct=EBI-18302142, EBI-9254454;
CC P55056; P07204: THBD; NbExp=3; IntAct=EBI-18302142, EBI-941422;
CC P55056; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-18302142, EBI-6268651;
CC P55056; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-18302142, EBI-8638294;
CC P55056; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-18302142, EBI-17249488;
CC P55056; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-18302142, EBI-741480;
CC P55056; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-18302142, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
CC -!- SIMILARITY: Belongs to the apolipoprotein C4 family. {ECO:0000305}.
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DR EMBL; U32576; AAA91653.1; -; Genomic_DNA.
DR EMBL; AY422953; AAQ91812.1; -; Genomic_DNA.
DR EMBL; AK126257; BAG54298.1; -; mRNA.
DR EMBL; CH471126; EAW57310.1; -; Genomic_DNA.
DR EMBL; BC020723; AAH20723.1; -; mRNA.
DR CCDS; CCDS12649.1; -.
DR RefSeq; NP_001637.1; NM_001646.2.
DR AlphaFoldDB; P55056; -.
DR BioGRID; 106843; 29.
DR IntAct; P55056; 23.
DR STRING; 9606.ENSP00000468236; -.
DR GlyConnect; 2021; 1 N-Linked glycan (1 site).
DR GlyGen; P55056; 1 site, 2 N-linked glycans (1 site).
DR iPTMnet; P55056; -.
DR PhosphoSitePlus; P55056; -.
DR BioMuta; APOC4; -.
DR DMDM; 1703333; -.
DR CPTAC; non-CPTAC-2626; -.
DR jPOST; P55056; -.
DR MassIVE; P55056; -.
DR PaxDb; P55056; -.
DR PeptideAtlas; P55056; -.
DR PRIDE; P55056; -.
DR ProteomicsDB; 56768; -.
DR Antibodypedia; 73673; 127 antibodies from 23 providers.
DR DNASU; 346; -.
DR Ensembl; ENST00000592954.2; ENSP00000468236.1; ENSG00000267467.4.
DR GeneID; 346; -.
DR KEGG; hsa:346; -.
DR MANE-Select; ENST00000592954.2; ENSP00000468236.1; NM_001646.3; NP_001637.1.
DR UCSC; uc060zuq.1; human.
DR CTD; 346; -.
DR DisGeNET; 346; -.
DR GeneCards; APOC4; -.
DR HGNC; HGNC:611; APOC4.
DR HPA; ENSG00000267467; Tissue enriched (liver).
DR MIM; 600745; gene.
DR neXtProt; NX_P55056; -.
DR OpenTargets; ENSG00000224916; -.
DR OpenTargets; ENSG00000267467; -.
DR PharmGKB; PA54; -.
DR VEuPathDB; HostDB:ENSG00000267467; -.
DR eggNOG; ENOG502TE52; Eukaryota.
DR GeneTree; ENSGT00390000007913; -.
DR GeneTree; ENSGT00390000015914; -.
DR HOGENOM; CLU_161459_0_0_1; -.
DR InParanoid; P55056; -.
DR OMA; KWQWFWG; -.
DR OrthoDB; 1563324at2759; -.
DR PhylomeDB; P55056; -.
DR TreeFam; TF336879; -.
DR PathwayCommons; P55056; -.
DR Reactome; R-HSA-8866423; VLDL assembly.
DR Reactome; R-HSA-8964046; VLDL clearance.
DR Reactome; R-HSA-9029569; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.
DR SignaLink; P55056; -.
DR BioGRID-ORCS; 346; 8 hits in 1052 CRISPR screens.
DR GeneWiki; Apolipoprotein_C4; -.
DR GenomeRNAi; 346; -.
DR Pharos; P55056; Tbio.
DR PRO; PR:P55056; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P55056; protein.
DR Bgee; ENSG00000267467; Expressed in right lobe of liver and 82 other tissues.
DR ExpressionAtlas; P55056; baseline and differential.
DR Genevisible; P55056; HS.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
DR GO; GO:0005319; F:lipid transporter activity; TAS:ProtInc.
DR GO; GO:0006629; P:lipid metabolic process; TAS:ProtInc.
DR GO; GO:0010890; P:positive regulation of sequestering of triglyceride; IMP:BHF-UCL.
DR GO; GO:0070328; P:triglyceride homeostasis; IMP:BHF-UCL.
DR InterPro; IPR028120; APOC4.
DR PANTHER; PTHR32288; PTHR32288; 1.
DR Pfam; PF15119; APOC4; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Lipid transport; Reference proteome; Secreted; Signal;
KW Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000250|UniProtKB:P55057"
FT CHAIN 28..127
FT /note="Apolipoprotein C-IV"
FT /id="PRO_0000002036"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16335952"
FT VARIANT 36
FT /note="L -> P (in dbSNP:rs1132899)"
FT /evidence="ECO:0000269|PubMed:10996355, ECO:0000269|Ref.2"
FT /id="VAR_012081"
FT VARIANT 52
FT /note="G -> D (in dbSNP:rs12691089)"
FT /evidence="ECO:0000269|PubMed:10996355"
FT /id="VAR_012082"
FT VARIANT 75
FT /note="P -> Q (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036540"
FT VARIANT 96
FT /note="L -> R (in dbSNP:rs5167)"
FT /evidence="ECO:0000269|PubMed:10996355"
FT /id="VAR_012068"
FT VARIANT 126
FT /note="Q -> L (in dbSNP:rs5168)"
FT /id="VAR_012069"
SQ SEQUENCE 127 AA; 14553 MW; D7C7F6F2CD922775 CRC64;
MSLLRNRLQA LPALCLCVLV LACIGACQPE AQEGTLSPPP KLKMSRWSLV RGRMKELLET
VVNRTRDGWQ WFWSPSTFRG FMQTYYDDHL RDLGPLTKAW FLESKDSLLK KTHSLCPRLV
CGDKDQG
