ID   INS_DANRE               Reviewed;         108 AA.
AC   O73727; Q504H9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
DE   Flags: Precursor;
GN   Name=ins;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9492081; DOI=10.1210/endo.139.3.5768;
RA   Milewski W.M., Duguay S.J., Chan S.J., Steiner D.F.;
RT   "Conservation of PDX-1 structure, function, and expression in zebrafish.";
RL   Endocrinology 139:1440-1449(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; AF036326; AAC41261.1; -; mRNA.
DR   EMBL; BC095013; AAH95013.1; -; mRNA.
DR   RefSeq; NP_571131.1; NM_131056.1.
DR   AlphaFoldDB; O73727; -.
DR   SMR; O73727; -.
DR   STRING; 7955.ENSDARP00000051221; -.
DR   PaxDb; O73727; -.
DR   Ensembl; ENSDART00000051222; ENSDARP00000051221; ENSDARG00000035350.
DR   Ensembl; ENSDART00000181413; ENSDARP00000155430; ENSDARG00000116735.
DR   Ensembl; ENSDART00000185283; ENSDARP00000153651; ENSDARG00000035350.
DR   GeneID; 30262; -.
DR   KEGG; dre:30262; -.
DR   CTD; 3630; -.
DR   ZFIN; ZDB-GENE-980526-110; ins.
DR   eggNOG; ENOG502S3FQ; Eukaryota.
DR   GeneTree; ENSGT00940000164327; -.
DR   HOGENOM; CLU_140421_1_0_1; -.
DR   InParanoid; O73727; -.
DR   OMA; LAFKDQM; -.
DR   OrthoDB; 1644517at2759; -.
DR   PhylomeDB; O73727; -.
DR   TreeFam; TF332820; -.
DR   Reactome; R-DRE-264876; Insulin processing.
DR   Reactome; R-DRE-422085; Synthesis, secretion, and deacylation of Ghrelin.
DR   Reactome; R-DRE-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   Reactome; R-DRE-74713; IRS activation.
DR   Reactome; R-DRE-74749; Signal attenuation.
DR   Reactome; R-DRE-74751; Insulin receptor signalling cascade.
DR   Reactome; R-DRE-74752; Signaling by Insulin receptor.
DR   Reactome; R-DRE-77387; Insulin receptor recycling.
DR   SignaLink; O73727; -.
DR   PRO; PR:O73727; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000035350; Expressed in spleen and 12 other tissues.
DR   ExpressionAtlas; O73727; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:2000252; P:negative regulation of feeding behavior; IMP:ZFIN.
DR   GO; GO:2000228; P:positive regulation of pancreatic A cell differentiation; IMP:ZFIN.
DR   GO; GO:0009749; P:response to glucose; IDA:ZFIN.
DR   GO; GO:0031667; P:response to nutrient levels; IDA:ZFIN.
DR   GO; GO:0003309; P:type B pancreatic cell differentiation; IMP:ZFIN.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Disulfide bond; Glucose metabolism; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         22..51
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015767"
FT   PROPEP          54..84
FT                   /note="C peptide"
FT                   /id="PRO_0000015768"
FT   PEPTIDE         88..108
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015769"
FT   DISULFID        30..94
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..107
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        93..98
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   108 AA;  11904 MW;  31D03CCF37BD2C22 CRC64;
     MAVWLQAGAL LVLLVVSSVS TNPGTPQHLC GSHLVDALYL VCGPTGFFYN PKRDVEPLLG
     FLPPKSAQET EVADFAFKDH AELIRKRGIV EQCCHKPCSI FELQNYCN