APOC4_MOUSE
ID APOC4_MOUSE Reviewed; 124 AA.
AC Q61268;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Apolipoprotein C-IV;
DE Short=Apo-CIV;
DE Short=ApoC-IV;
DE AltName: Full=Apolipoprotein C2-linked;
DE Short=ACL;
DE AltName: Full=Apolipoprotein C4;
DE Flags: Precursor;
GN Name=Apoc4; Synonyms=Acl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=8088778; DOI=10.1006/geno.1994.1231;
RA van Eck M.M., Hoffer M.J., Havekes L.M., Frants R.R., Hofker M.H.;
RT "The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse
RT apolipoprotein e-c1-c2 gene cluster.";
RL Genomics 21:110-115(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Liver, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May participate in lipoprotein metabolism.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
CC -!- SIMILARITY: Belongs to the apolipoprotein C4 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z24722; CAA80850.1; -; Genomic_DNA.
DR EMBL; BC024657; AAH24657.1; -; mRNA.
DR CCDS; CCDS20910.1; -.
DR PIR; A54773; A54773.
DR RefSeq; NP_031411.1; NM_007385.3.
DR AlphaFoldDB; Q61268; -.
DR STRING; 10090.ENSMUSP00000003071; -.
DR GlyGen; Q61268; 1 site.
DR PhosphoSitePlus; Q61268; -.
DR CPTAC; non-CPTAC-3419; -.
DR MaxQB; Q61268; -.
DR PaxDb; Q61268; -.
DR PeptideAtlas; Q61268; -.
DR PRIDE; Q61268; -.
DR ProteomicsDB; 296338; -.
DR Antibodypedia; 73673; 127 antibodies from 23 providers.
DR DNASU; 11425; -.
DR Ensembl; ENSMUST00000003071; ENSMUSP00000003071; ENSMUSG00000074336.
DR GeneID; 11425; -.
DR KEGG; mmu:11425; -.
DR UCSC; uc009fmu.2; mouse.
DR CTD; 346; -.
DR MGI; MGI:87878; Apoc4.
DR VEuPathDB; HostDB:ENSMUSG00000074336; -.
DR eggNOG; ENOG502TE52; Eukaryota.
DR GeneTree; ENSGT00390000015914; -.
DR HOGENOM; CLU_161459_0_0_1; -.
DR InParanoid; Q61268; -.
DR OMA; KWQWFWG; -.
DR OrthoDB; 1563324at2759; -.
DR PhylomeDB; Q61268; -.
DR TreeFam; TF336879; -.
DR Reactome; R-MMU-8866423; VLDL assembly.
DR Reactome; R-MMU-8964046; VLDL clearance.
DR BioGRID-ORCS; 11425; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q61268; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q61268; protein.
DR Bgee; ENSMUSG00000074336; Expressed in left lobe of liver and 39 other tissues.
DR Genevisible; Q61268; MM.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0034364; C:high-density lipoprotein particle; ISO:MGI.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0010890; P:positive regulation of sequestering of triglyceride; ISO:MGI.
DR GO; GO:0070328; P:triglyceride homeostasis; ISO:MGI.
DR InterPro; IPR028120; APOC4.
DR PANTHER; PTHR32288; PTHR32288; 1.
DR Pfam; PF15119; APOC4; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Lipid transport; Reference proteome; Secreted; Signal;
KW Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000250|UniProtKB:P55057"
FT CHAIN 28..124
FT /note="Apolipoprotein C-IV"
FT /id="PRO_0000002037"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 124 AA; 14288 MW; 97C3CDEE72C9A452 CRC64;
MSLLRCRPRD LPSVSLSVLF LVSFVASMST ESLSPTPGPE SSRWSLVRAR VLEMVEPLVT
RTRDRWQWFW GPGAVQGFMQ TYYEDHLKDL GPRTQAWLQS SRDHLLNKTH SLCPRLLCKD
RTQG
