ID   INS_LAMFL               Reviewed;          57 AA.
AC   P68988; P14806; Q9PRR1; Q9PRR2;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=ins;
OS   Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Lampetra.
OX   NCBI_TaxID=7748;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=8575665; DOI=10.1006/gcen.1995.1138;
RA   Conlon J.M., Bondareva V., Rusakov Y., Plisetskaya E.M., Mynarcik D.C.,
RA   Whittaker J.;
RT   "Characterization of insulin, glucagon, and somatostatin from the river
RT   lamprey, Lampetra fluviatilis.";
RL   Gen. Comp. Endocrinol. 100:96-105(1995).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   AlphaFoldDB; P68988; -.
DR   SMR; P68988; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 2.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015828"
FT   PEPTIDE         37..57
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015829"
FT   DISULFID        12..43
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        24..56
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        42..47
FT   NON_CONS        36..37
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   57 AA;  6207 MW;  64029669D2CDB337 CRC64;
     SALTGAGGTH LCGSHLVEAL YVVCGDRGFF YTPSKTGIVE QCCHRKCSIY DMENYCN