ID   INS_MACFA               Reviewed;         110 AA.
AC   P30406; P01309;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
DE   Flags: Precursor;
GN   Name=INS;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6184262; DOI=10.1016/0378-1119(82)90004-x;
RA   Wetekam W., Groneberg J., Leineweber M., Wengenmayer F., Winnacker E.-L.;
RT   "The nucleotide sequence of cDNA coding for preproinsulin from the primate
RT   Macaca fascicularis.";
RL   Gene 19:179-183(1982).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds. {ECO:0000250|UniProtKB:P01308}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; J00336; AAA36849.1; -; mRNA.
DR   PIR; JQ0178; JQ0178.
DR   RefSeq; NP_001271848.1; NM_001284919.1.
DR   RefSeq; XP_015289666.1; XM_015434180.1.
DR   AlphaFoldDB; P30406; -.
DR   BMRB; P30406; -.
DR   SMR; P30406; -.
DR   STRING; 9541.XP_005576939.1; -.
DR   GeneID; 102133184; -.
DR   KEGG; mcf:102133184; -.
DR   CTD; 3630; -.
DR   VEuPathDB; HostDB:ENSMFAG00000000997; -.
DR   eggNOG; ENOG502S5P5; Eukaryota.
DR   OMA; LANQHLC; -.
DR   OrthoDB; 1438615at2759; -.
DR   Proteomes; UP000233100; Chromosome 14.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Disulfide bond; Glucose metabolism; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT   PEPTIDE         25..54
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015837"
FT   PROPEP          57..87
FT                   /note="C peptide"
FT                   /id="PRO_0000015838"
FT   PEPTIDE         90..110
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015839"
FT   DISULFID        31..96
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250|UniProtKB:P01308"
FT   DISULFID        43..109
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250|UniProtKB:P01308"
FT   DISULFID        95..100
FT                   /evidence="ECO:0000250|UniProtKB:P01308"
SQ   SEQUENCE   110 AA;  11991 MW;  83C6E33A80A420F9 CRC64;
     MALWMRLLPL LALLALWGPD PAPAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED
     PQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC SLYQLENYCN