ID   INS_MYOCO               Reviewed;          51 AA.
AC   P01330;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=INS;
OS   Myocastor coypus (Coypu) (Nutria).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha;
OC   Myocastoridae; Myocastor.
OX   NCBI_TaxID=10157;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Smith L.F.;
RT   "Amino acid sequences of insulins.";
RL   Diabetes 21 Suppl. 2:457-460(1972).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=3541911; DOI=10.1042/bj2380345;
RA   Bajaj M., Blundell T.L., Horuk R., Pitts J.E., Wood S.P., Gowan L.K.,
RA   Schwabe C., Wollmer A., Gliemann J., Gammeltoft S.;
RT   "Coypu insulin. Primary structure, conformation and biological properties
RT   of a hystricomorph rodent insulin.";
RL   Biochem. J. 238:345-351(1986).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; A01596; INCU.
DR   AlphaFoldDB; P01330; -.
DR   SMR; P01330; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 2.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015848"
FT   PEPTIDE         30..51
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015849"
FT   DISULFID        7..36
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        19..49
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        35..40
FT   NON_CONS        29..30
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   51 AA;  5897 MW;  0812CFD83BAD3ACF CRC64;
     YVSQRLCGSQ LVDTLYSVCR HRGFYRPNDG IVDQCCTNIC SRNQLMSYCN D