ID   INS_ORNAN               Reviewed;          51 AA.
AC   Q9TQY7; Q9TQY8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=INS;
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=8868070; DOI=10.1515/bchm3.1996.377.2.147;
RA   Nourse A., Treacy G.B., Shaw D.C., Jeffrey P.D.;
RT   "Platypus insulin: indications from the amino acid sequence of significant
RT   differences in structure from porcine insulin.";
RL   Biol. Chem. Hoppe-Seyler 377:147-153(1996).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; S63591; S63590.
DR   AlphaFoldDB; Q9TQY7; -.
DR   SMR; Q9TQY7; -.
DR   InParanoid; Q9TQY7; -.
DR   Proteomes; UP000002279; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 2.
DR   Pfam; PF00049; Insulin; 2.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Reference proteome; Secreted.
FT   PEPTIDE         1..30
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015868"
FT   PEPTIDE         31..51
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015869"
FT   DISULFID        7..37
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        19..50
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        36..41
FT   NON_CONS        30..31
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   51 AA;  5854 MW;  0E4D30265D77EAA3 CRC64;
     FPNQHLCGSH LVEALYLVCG EKGFYYIPRM GIVEECCKGV CSMYQLENYC N