ID   INS_PANTR               Reviewed;         110 AA.
AC   P30410;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
DE   Flags: Precursor;
GN   Name=INS;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1560757; DOI=10.1093/oxfordjournals.molbev.a040713;
RA   Seino S., Bell G.I., Li W.;
RT   "Sequences of primate insulin genes support the hypothesis of a slower rate
RT   of molecular evolution in humans and apes than in monkeys.";
RL   Mol. Biol. Evol. 9:193-203(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12952878; DOI=10.1101/gr.948003;
RA   Stead J.D.H., Hurles M.E., Jeffreys A.J.;
RT   "Global haplotype diversity in the human insulin gene region.";
RL   Genome Res. 13:2101-2111(2003).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; X61089; CAA43403.1; -; Genomic_DNA.
DR   EMBL; AY137497; AAN06933.1; -; Genomic_DNA.
DR   PIR; A42179; A42179.
DR   RefSeq; NP_001008996.1; NM_001008996.2.
DR   PDB; 1BZV; NMR; -; B=25-49.
DR   PDBsum; 1BZV; -.
DR   AlphaFoldDB; P30410; -.
DR   BMRB; P30410; -.
DR   SMR; P30410; -.
DR   STRING; 9598.ENSPTRP00000005606; -.
DR   PaxDb; P30410; -.
DR   Ensembl; ENSPTRT00000006075; ENSPTRP00000005606; ENSPTRG00000003172.
DR   GeneID; 449570; -.
DR   KEGG; ptr:449570; -.
DR   CTD; 3630; -.
DR   VGNC; VGNC:1070; INS.
DR   eggNOG; ENOG502S5P5; Eukaryota.
DR   GeneTree; ENSGT00390000015440; -.
DR   HOGENOM; CLU_140421_1_0_1; -.
DR   InParanoid; P30410; -.
DR   OMA; IVEQCCN; -.
DR   OrthoDB; 1438615at2759; -.
DR   TreeFam; TF332820; -.
DR   EvolutionaryTrace; P30410; -.
DR   Proteomes; UP000002277; Chromosome 11.
DR   Bgee; ENSPTRG00000003172; Expressed in liver and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042593; P:glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0050714; P:positive regulation of protein secretion; IBA:GO_Central.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Disulfide bond; Glucose metabolism; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         25..54
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015870"
FT   PROPEP          57..87
FT                   /note="C peptide"
FT                   /id="PRO_0000015871"
FT   PEPTIDE         90..110
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015872"
FT   DISULFID        31..96
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..109
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        95..100
FT                   /evidence="ECO:0000250"
FT   HELIX           33..43
FT                   /evidence="ECO:0007829|PDB:1BZV"
FT   STRAND          44..46
FT                   /evidence="ECO:0007829|PDB:1BZV"
SQ   SEQUENCE   110 AA;  12025 MW;  41EB8DF79837CEF5 CRC64;
     MALWMRLLPL LVLLALWGPD PASAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED
     LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC SLYQLENYCN