ID   INS_PLAFE               Reviewed;          51 AA.
AC   P09477;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=ins;
OS   Platichthys flesus (European flounder) (Pleuronectes flesus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Platichthys.
OX   NCBI_TaxID=8260;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3556313; DOI=10.1016/0016-6480(87)90268-1;
RA   Conlon J.M., Davis M.S., Thim L.;
RT   "Primary structure of insulin and glucagon from the flounder (Platichthys
RT   flesus).";
RL   Gen. Comp. Endocrinol. 66:203-209(1987).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; S07213; INFLE.
DR   AlphaFoldDB; P09477; -.
DR   SMR; P09477; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 2.
DR   Pfam; PF00049; Insulin; 2.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..30
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015882"
FT   PEPTIDE         31..51
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015883"
FT   DISULFID        8..37
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        20..50
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        36..41
FT   NON_CONS        30..31
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   51 AA;  5755 MW;  04A232C873FF705B CRC64;
     VVPPQHLCGA HLVDALYLVC GERGFFYTPK GIVEQCCHKP CNIFDLQNYC N