ID   INS_POLSE               Reviewed;          52 AA.
AC   P0C236;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=ins;
OS   Polypterus senegalus (Senegal bichir).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Polypteriformes; Polypteridae; Polypterus.
OX   NCBI_TaxID=55291;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=9446726; DOI=10.1006/gcen.1997.7007;
RA   Conlon J.M., Fan H.-Y., Fritzsch B.;
RT   "Purification and structural characterization of insulin and glucagon from
RT   the bichir Polypterus senegalis (Actinopterygii: Polypteriformes).";
RL   Gen. Comp. Endocrinol. 109:86-93(1998).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   AlphaFoldDB; P0C236; -.
DR   SMR; P0C236; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 2.
DR   Pfam; PF00049; Insulin; 2.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..31
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000261314"
FT   PEPTIDE         32..52
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000261315"
FT   DISULFID        7..38
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        19..51
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        37..42
FT   NON_CONS        31..32
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   52 AA;  5817 MW;  EB7D85400E016B3F CRC64;
     AANRHLCGSH LVEALYLVCG NRGFFYIPSK MGIVEQCCDT PCSLYDPENY CN