ID   INS_PROGU               Reviewed;          50 AA.
AC   P01331;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=INS;
OS   Proechimys guairae (Guaira spiny rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Echimyidae;
OC   Proechimys.
OX   NCBI_TaxID=10163;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=16068186; DOI=10.1038/279439a0;
RA   Horuk R., Goodwin P., O'Connor K., Neville R.W.J., Lazarus N.R., Stone D.;
RT   "Evolutionary change in the insulin receptors of hystricomorph rodents.";
RL   Nature 279:439-440(1979).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; A01597; INKS.
DR   AlphaFoldDB; P01331; -.
DR   SMR; P01331; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..29
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015887"
FT   PEPTIDE         30..50
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015888"
FT   DISULFID        7..36
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        19..49
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        35..40
FT   NON_CONS        29..30
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   50 AA;  5707 MW;  BD24AEFFBC8B1961 CRC64;
     YVGQRLCGSQ LVDTLYSVCK HRGFYRPSEG IVDQCCTNIC SRNQLLTYCN