ID   INS_SELRF               Reviewed;         103 AA.
AC   P51463;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
DE   Flags: Precursor; Fragment;
GN   Name=INS;
OS   Selasphorus rufus (Rufous hummingbird) (Trochilus rufus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Apodiformes;
OC   Trochilidae; Selasphorus.
OX   NCBI_TaxID=29060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8405887; DOI=10.1006/gcen.1993.1100;
RA   Fan L., Gardner P., Chan S.J., Steiner D.F.;
RT   "Cloning and analysis of the gene encoding hummingbird proinsulin.";
RL   Gen. Comp. Endocrinol. 91:25-30(1993).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   EMBL; AH006925; AAC64211.1; -; Genomic_DNA.
DR   PIR; I51221; I51221.
DR   AlphaFoldDB; P51463; -.
DR   SMR; P51463; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cleavage on pair of basic residues;
KW   Disulfide bond; Glucose metabolism; Hormone; Secreted; Signal.
FT   SIGNAL          <1..20
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         21..50
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015906"
FT   PROPEP          53..80
FT                   /note="C peptide"
FT                   /id="PRO_0000015907"
FT   PEPTIDE         83..103
FT                   /note="Insulin A chain"
FT                   /id="PRO_0000015908"
FT   DISULFID        27..89
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..102
FT                   /note="Interchain (between B and A chains)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..93
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   103 AA;  11378 MW;  6598520B28F5BB9C CRC64;
     IQSLPLLALL ALSGPGTSHA AVNQHLCGSH LVEALYLVCG ERGFFYSPKA RRDAEHPLVN
     GPLHGEVGDL PFQQEEFEKV KRGIVEQCCH NTCSLYQLEN YCN