ID   INS_SQUAC               Reviewed;          54 AA.
AC   P12704;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   02-DEC-2020, entry version 85.
DE   RecName: Full=Insulin;
DE   Contains:
DE     RecName: Full=Insulin B chain;
DE   Contains:
DE     RecName: Full=Insulin A chain;
GN   Name=ins;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6352261; DOI=10.1111/j.1432-1033.1983.tb07685.x;
RA   Bajaj J., Blundell T.L., Pitts J.E., Wood S.P., Tatnell M.A., Falkmer S.,
RA   Emdin S.O., Gowan L.K., Crow H., Schwabe C., Wollmer A., Strassburger W.;
RT   "Dogfish insulin. Primary structure, conformation and biological properties
RT   of an elasmobranchial insulin.";
RL   Eur. J. Biochem. 135:535-542(1983).
CC   -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC       cell permeability to monosaccharides, amino acids and fatty acids. It
CC       accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC       synthesis in liver.
CC   -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC       disulfide bonds.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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DR   PIR; S07220; INDF.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04367; IlGF_insulin_like; 1.
DR   InterPro; IPR004825; Insulin.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR11454; PTHR11454; 2.
DR   Pfam; PF00049; Insulin; 2.
DR   PRINTS; PR00277; INSULIN.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; SSF56994; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Direct protein sequencing; Disulfide bond;
KW   Glucose metabolism; Hormone; Secreted.
FT   PEPTIDE         1..32
FT                   /note="Insulin B chain"
FT                   /id="PRO_0000015915"
FT   PEPTIDE         33..54
FT                   /note="Insulin A chain"
FT                   /evidence="ECO:0000269|PubMed:6352261"
FT                   /id="PRO_0000015916"
FT   DISULFID        7..39
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        19..52
FT                   /note="Interchain (between B and A chains)"
FT   DISULFID        38..43
FT   NON_CONS        32..33
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   54 AA;  6094 MW;  BC768929BE82F36B CRC64;
     LPSQHLCGSH LVEALYFVCG PKGFYYLPKB ZVGIVEHCCH NTCSLYDLEG YCNQ