ID   INT10_CHICK             Reviewed;         710 AA.
AC   Q5ZLS8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Integrator complex subunit 10;
DE            Short=Int10;
GN   Name=INTS10; ORFNames=RCJMB04_4p16;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 10 family. {ECO:0000305}.
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DR   EMBL; AJ719656; CAG31315.1; -; mRNA.
DR   RefSeq; NP_001034386.1; NM_001039297.1.
DR   AlphaFoldDB; Q5ZLS8; -.
DR   STRING; 9031.ENSGALP00000016456; -.
DR   PaxDb; Q5ZLS8; -.
DR   GeneID; 422489; -.
DR   KEGG; gga:422489; -.
DR   CTD; 55174; -.
DR   VEuPathDB; HostDB:geneid_422489; -.
DR   eggNOG; ENOG502QQ28; Eukaryota.
DR   HOGENOM; CLU_023740_0_0_1; -.
DR   InParanoid; Q5ZLS8; -.
DR   OrthoDB; 732482at2759; -.
DR   PhylomeDB; Q5ZLS8; -.
DR   TreeFam; TF323935; -.
DR   PRO; PR:Q5ZLS8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0016180; P:snRNA processing; IBA:GO_Central.
DR   InterPro; IPR026164; Int_cplx_su10.
DR   PANTHER; PTHR16055; PTHR16055; 1.
DR   PRINTS; PR02106; INTSUBUNIT10.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..710
FT                   /note="Integrator complex subunit 10"
FT                   /id="PRO_0000235690"
FT   REGION          366..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..393
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  81832 MW;  11096A64CDF2080E CRC64;
     MSAQGDCEFL VKRARELVPG DLWAAKAWLI TARSLYPADF NIQYEMYTIE RNAERTASAG
     RLLYDMFVNF PDQPAVWREI SVITAALRND SQDKQTQFLR GLFETLPGRV QCEMLLKATE
     QCFNTLERAE MLLLLLRRFP ETVVQHGVGL GETLLEAENI EDQESPVNCF RKLFVCDVLP
     LIINNPDVRL PASLLYKYLN KAAEFYINYV TRSTQTESQY QGSQDSSDLM SPSKRSSQKY
     IIDGLTEKSS QITDPWERLF KILSVVGMRC EWQMDKGRRS FGDILHRMKD LCRYISNFDS
     DAHAKYKNQV VYSTMLVFFK NAFQYVSNIQ PSLFQGPNAP NQAPLILLED VTNVYGDTDI
     DRNKHIHKKR KLAEGREKTM SSDDEDPSGK ARSRHIAVNK ADLANSIEVL ESFKLARESW
     ELLCSLESLD KEFTRICLSW KTETWLWLRI FLTDMIIYQG QYKKAISSLH HLAALQGSHS
     PQQITGQGSL ENQRALIQLA TCHFALGEYR QTCEKVLDLM CYILLPIQEG GKVQEEQPKV
     KSKFRKGSDL KLWPCTSRAI MPYCLHLLLA CFKLRAFTDN RDDTALGHVI VLLQHEWPRG
     ENLFLKAINK ICQQGNFQYE NFFNYVTNID MLEEFAYLRT QEGGKIHLEL LPNQGMLIKH
     HTVTRGITKG VKEDFRLAME RQVSRCGENL MVVLHRFCIN EKILLLQTLS