ID   INT10_DANRE             Reviewed;         715 AA.
AC   Q6TNU3;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Integrator complex subunit 10;
DE            Short=Int10;
GN   Name=ints10; ORFNames=zgc:111853;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved in
CC       the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-
CC       box-dependent processing. {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 10 family. {ECO:0000305}.
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DR   EMBL; AY391424; AAQ91236.1; -; mRNA.
DR   RefSeq; NP_997804.1; NM_212639.1.
DR   AlphaFoldDB; Q6TNU3; -.
DR   STRING; 7955.ENSDARP00000110172; -.
DR   PaxDb; Q6TNU3; -.
DR   GeneID; 323368; -.
DR   KEGG; dre:323368; -.
DR   CTD; 55174; -.
DR   ZFIN; ZDB-GENE-050522-2; ints10.
DR   eggNOG; ENOG502QQ28; Eukaryota.
DR   InParanoid; Q6TNU3; -.
DR   PhylomeDB; Q6TNU3; -.
DR   Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR   PRO; PR:Q6TNU3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IBA:GO_Central.
DR   GO; GO:0016180; P:snRNA processing; IBA:GO_Central.
DR   InterPro; IPR026164; Int_cplx_su10.
DR   PANTHER; PTHR16055; PTHR16055; 1.
DR   PRINTS; PR02106; INTSUBUNIT10.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..715
FT                   /note="Integrator complex subunit 10"
FT                   /id="PRO_0000235691"
FT   REGION          220..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  81159 MW;  04B86E16349963B0 CRC64;
     MSAQGDCEFL VKRARELVPQ DPYAAKAWLI TARTLYPTDF NIQYEMYSIE RNAERTSSAG
     RLLYDIFVNF PDQPVVWREI SAITAALRND SQDKHAQFLK GVFETLPGQV QCKMLLKATE
     QCFNTLEKAE MLLLLLKRFP ESVVQHGVSL GESLLEAESV EDLETPVNCF RKLFVCDVLP
     LILNNPEMCL PVSLLYKYLH KAAEFYICYV TREPSADGQM QGSQEVGGLN SPGRGRGQRS
     VIDGLSDKAS VVTEPWDRLL EMVGVVGSLC DWQGEKGSRS YAELLQRVSD LCRFLSAADA
     DGFSRCCSQI VSCCTLVLFH CAFHYVSAVQ PSLFQGHSSL SSGPWVLLED LSSVYADVEV
     ERKHTHKKRK LADGREKTMS SDDEDVLAKG RGRHIVVSKS EMLNWAETLD HFRTARESWD
     LLHSHPSLEA EFAKICSAWK TEMWLWFRIF LTDMIIYQGQ YRKALSSLAL MSSLQLQQNQ
     NQNQNSLQTG SSSSLENHRA VIQQASCHYA LGEYRLACEK LLEAVGGLLP QNQEFVKSSD
     EQRKPRSKTR RGNDLRLVPC TSKSILPFCL QLMLACFKLR AFTDNRDDLA LGHVIVLLQF
     DWPQGESLFL KAVDKICQQG SFQYENFFNY VTNIDMLEEF AYLRTTEGGR VQLELLPNQG
     MLIKHHTVTR GITKGVKEDF RLAMERQVSR CGENLLMVLH RFCINEKIIL IQSLP