ID   INT10_MACFA             Reviewed;         699 AA.
AC   Q4R7B1;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Integrator complex subunit 10;
DE            Short=Int10;
GN   Name=INTS10; ORFNames=QtsA-15722;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Integrator (INT) complex, a complex involved
CC       in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their
CC       3'-box-dependent processing. The Integrator complex is associated with
CC       the C-terminal domain (CTD) of RNA polymerase II largest subunit
CC       (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May be not
CC       involved in the recruitment of cytoplasmic dynein to the nuclear
CC       envelope by different components of the INT complex.
CC       {ECO:0000250|UniProtKB:Q9NVR2}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8,
CC       INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Interacts with POLR2A.
CC       {ECO:0000250|UniProtKB:Q9NVR2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NVR2}.
CC   -!- SIMILARITY: Belongs to the Integrator subunit 10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE01011.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB168910; BAE01011.1; ALT_FRAME; mRNA.
DR   AlphaFoldDB; Q4R7B1; -.
DR   STRING; 9541.XP_005562775.1; -.
DR   eggNOG; ENOG502QQ28; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016180; P:snRNA processing; IEA:InterPro.
DR   InterPro; IPR026164; Int_cplx_su10.
DR   PANTHER; PTHR16055; PTHR16055; 1.
DR   PRINTS; PR02106; INTSUBUNIT10.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..699
FT                   /note="Integrator complex subunit 10"
FT                   /id="PRO_0000235688"
FT   MOD_RES         220
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVR2"
FT   MOD_RES         370
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K2A7"
FT   CROSSLNK        453
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVR2"
SQ   SEQUENCE   699 AA;  81065 MW;  1A3E98852F3B1925 CRC64;
     MSAQGDCEFL VQRAREWLIT ARSLYPADFN IQYEMYTIER NAERTATAGR LLYDMFVNFP
     DQPVVWREIS IIISALRNDS QDKQTQFLRS LFETLPGRVQ CEMLLKVTEQ CFNTLERSEM
     LLLLLRRFPE TVVQHGVGLG EALLEAETIE EQESPVNCFR KLFVCDVLPL IINNHDVRLP
     ANLLYKYLNK AAEFYINYVT RSTQTENQHQ GAQDTSDLMS PSKRSSQKYI IEGLTEKSSQ
     IVDPWERLFK ILNVVGMRCE WQMDKGRRSY GDILHRMKDL CRYMNNFDSE AHAKYKNQVV
     YSTMLVFFKN AFQYVNSIQP SLFQGPNAPS QVPLVLLEDV SNVYGDVEID RNKHIHKKRK
     LAEGREKTMS PDDEDCSAKG RNRHIVVNKA ELANSIEVLE SFKLARESWE LLYSLEFLDK
     EFTRICLAWK TDTWLWLRIF LTDMIIYQGQ YKKAIASLHH LAALQGSISQ PQITGQGTLE
     HQRALIQLAT CHFALGEYRM TCEKVLDLMC YMVLPIQDGG KSQEEPSKVK PKFRKGSDLK
     LLPCTSKAIM PYCLHLMLAC FKLRAFTDNR DDMALGHVIV LLQQEWPRGE NLFLKAVNKI
     CQQGNFQYEN FFNYVTNIDM LEEFAYLRTQ EGGKIHLELL PNQGMLIKHH TVTRGITKGV
     KEDFRLAMER QVSRCGENLM VVLHRFCINE KILLLQTLT